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Institute of Bioorganic Chemistry,
Polish Academy of Sciences
Z. Noskowskiego 12/14
61-704 Poznań
tel centrala: (+48) 61 852 85 03
fax: (+48) 61 852 05 32
e-mail: ibch@ibch.poznan.pl

Sekretariat Dyrektora, tel: 61 852 89 19

Address

Research projects

The main source of funding for the Institute's research and development activities are grants obtained in open Polish and foreign competitions. The Institute receives funds for research from the National Science Center, the National Center for Research and Development, the European Regional Development Fund, the European Commission, the Foundation for Polish Science, the Ministry of Science and Higher Education, the European Molecular Biology Organization and a number of others.

PSNC projects

National Science Center

Agreement number

Title

 Principal Investigator

Start date

End date

Project type

2020/37/B/NZ7/02008

Foldback triplex-forming oligonucleotides as novel tools for G-quadruplex unfolding and selective inhibition of c-Myc oncogene transcription

Anna Pasternak

01.04.2021

31.03.2025

Opus 19

2020/37/B/ST4/03182

Lanthanide binding oligonucleotides (LBOs) as paramagnetic tags for NMR spectroscopy of nucleic acids

Witold Andrałojć

01.04.2021

31.03.2025

Opus 19

2020/37/B/NZ3/03633

Non-coding RNAs at single-cell resolution in the pituitary gland and their role in the regulation of gene expression

Monika Piwecka

01.02.2021

31.01.2025

Opus 19

2020/37/B/NZ5/03249

Application of small compounds in the epigenetic therapy of malignant brain gliomas

Mirosława Naskręt-Barciszewska

01.02.2021

31.01.2024

Opus 19

2020/37/B/NZ1/03250

Novel L-asparaginases as potential therapeutic agents and antimicrobial targets: structural and functional studies of enzymes with dual implications for drug design

Mariusz Jaskólski

01.02.2021

31.01.2025

Opus 19

2020/04/X/NZ1/01959

Preliminary research on the chemical programming of fungi using Ramularia collo-cygni as a model

Dorota Jakubczyk

12.12.2020

11.12.2021

Miniatura 3

2020/04/X/NZ7/01461

Analysis of apro-regenerative and antioxidant properties of 4-N-furfurylcytosine in an animal model of Schmidtea mediterranea (Planaria)

Agnieszka  Fedoruk-Wyszomirska

12.12.2020

11.12.2021

Miniatura 4

2019/33/B/NZ5/02473

Deciphering the molecular causes and consequences of circular RNAs elevated expression levels in myotonic dystrophy type 1(DM1)

Marzena Wojciechowska

27.11.2020

26.11.2023

Opus 17

2020/04/X/NZ3/00731

Experimental walidation of spinocerebellar ataxia type 3 pathogenesis markers that were identified by high throughput methods

Grzegorz Figura

19.11.2020

18.11.2021

Miniatura 4

2019/35/B/NZ2/02658

Comprehensive analysis of the Schmidtea mediterranea transcriptome – identification of non-coding RNAs involved in cell lineage development during regeneration

Paulina Jackowiak

02.11.2020

01.11.2024

Opus 18

2019/34/A/NZ3/00223

COLD-INDUCED TORPOR: Molecular mechanisms and manipulation for enhanced cellular preservation

Rafał Ciosk

01.10.2020

18.03.2021

Maestro 11

2020/36/T/NZ2/00127

The use of genome editing systems in experimental therapy of polyglutamine diseases

Magdalena Dąbrowska

01.10.2020

30.09.2021

Etiuda 8

2019/35/O/NZ1/03535

Allele-selective therapy for polyglutamine diseases with the use of RNA interference technology

Marta Olejniczak

01.10.2020

30.09.2024

Preludium Bis 1

2019/35/B/NZ3/03503

REGE-1 and RLE-1-dependent mRNA decay: The “R2-co” model of messenger RNA silencing

Rafał Ciosk

30.09.2020

18.03.2021

Opus 18

2019/35/B/NZ1/03731

Interspecies metabolic engineering as a tool to investigate immune functions of plant specialized metabolites

Paweł Bednarek

30.09.2020

29.09.2024

Opus 18

2020/36/C/NZ9/00221

Antibiotic resistance genes and integrons as indicators of biotic pollution and resistance load of Arctic ecosystems

Nicoletta Makowska

02.09.2020

01.09.2023

Sonatina 4

2019/35/D/NZ6/01479

The G-rich sequences in the influenza A virus genome – structural features and potential biological function in viral replication cycle

Marta Szabat

01.09.2020

31.08.2023

Sonata 15

2019/35/N/NZ7/02777

Novel bispecific G-quadruplex conjugates as potential anticancer agents

Carolina Pereira Roxo

06.07.2020

05.07.2023

Preludium 18

2019/35/D.NZ7/03637

Chemical architecture of fluorinated nucleoside dimers containing 1,2,3-triazole linker of potential use in molecular biology and medicine

Dagmara Baraniak

25.06.2020

24.06.2023

Sonata 15

2019/35/N/NZ1/01954

Arc as a neuronal Gag. Exploring the viral properties and functions of a master regulator of synaptic plasticity

Julita Gumna

19.06.2020

18.06.2022

Preludium 18

2019/35/B/ST4/03559

Exploring the sequence-structure relationship as a starting point for the design of DNA G-quadruplexes with a given topology - an integrative approach combining molecular simulations with experimental methods

Zofia Gdaniec

19.06.2020

18.06.2024

Opus 18

2020/01/0/NZ6/00137

SARS-CoV-2 RNA, target for inhibition of virus replication

Elżbieta Kierzek

15.06.2020

14.12.2021

Fast Track COVID-19

2020/01/0/NZ6/00152

TMPRSS2 – a potential new drug target and a determinant of  COVID19 outcome

Paweł Zmora

05.06.2020

04.12.2021

Fast Track COVID-19

2020/01/0/NZ1/00134

Validation of  PDB models of potential drug design targets for SARS-CoV-2 coronavirus

Mariusz Jaskólski

05.06.2020

04.12.2021

Fast Track COVID-19

2019/33/B/NZ1/02260

Defining roles of LINE-1 mRNA 5’ and 3’ ends in the retrotransposon biology

Zbigniew Warkocki

02.03.2020

01.01.2024

Opus 17

2019/33/B/ST4/01422

Thermodynamic parameters and rules towards the determination of RNA folding in in vivo-like conditions. RNA folding predictions for a better understanding of their structure and function in mammalian cells

Ryszard Kierzek

25.02.2020

24.02.2023

Opus 17

2018/31/F/NZ1/03891

Molecular basis for influenza virus activation by type II transmembrane serine proteases

Paweł Zmora

15.01.2020

14.01.2023

Beethoven Life 1

2019/03/X/ST4/00828

Functionalization of nucleic acids by means of thermo-sensitive switches

Jolanta Brzezińska

19.12.2019

18.08.2021

Miniatura 3

2019/03/X/NZ2/00739

Point mutations of the SOD1 gene as targets for the allele-selective antisense strategy

Dorota Magner

22.11.2019

21.11.2020

Miniatura 3

2019/03/X/NZ4/00286

The effect of normal and mutated ataxin 3 on the immune system in the context of pathogenesis of cerebellum cerebellar ataxia type 3

Łukasz Przybył

07.11.2019

06.11.2020

Miniatura 3

2019/03/X/ST4/00197

Synthesis and characterization of pH-dependent probe conjugates and oligonucleotides forming tryplex structures

Michał Gładysz

07.11.2019

06.11.2020

Miniatura 3

2018/30/E/NZ3/00624

Functional implications of brain-enriched circular RNAs

Monika Piwecka

04.11.2019

03.11.2023

Sonata Bis 8

2019/03/X/NZ1/00027

Study of the secondary structure of the 5' terminal region of the Δ133p53 mRNA encoding the Δ133p53 and Δ160p53 p53 isoforms and determination of the properties of this region in the translation process

Paulina Żydowicz-Machtel

10.10.2019

09.10.2020

Miniatura 3

2019/32/T/NZ3/00504

Discovering the molecular mechanisms of neurodegeneration in Ki91 knock-in mouse model during progression of spinocerebellar ataxia type 3

Kalina Wiatr

01.10.2019

30.09.2020

Etiuda 7

2018/31/B/NZ3/03621

Discovering disorders of brain development in Huntington disease as a consequence of putative total huntingtin deficiency in HD, using juvenile HD iPSC and fused brain organoids

Maciej Figiel

30.09.2019

29.09.2023

Opus 16

2018/31/D/NZ1/03630

Histidine Biosynthetic Pathway in Plants: Structural and Functional Studies as a Framework for the Design of Inhibitors and Activators

Miłosz Ruszkowski

26.09.2019

25.09.2022

Sonata 14

2018/31/B/NZ1/03580

Mechanisms and developmental roles of transcription termination

Takashi Miki

03.09.2019

02.09.2022

Opus 16

2018/31/B/NZ2/01940

Shedding new light on genome's dark matter: identification of novel long non-coding RNAs in zebrafish

Barbara Uszczyńska-Ratajczak

03.09.2019

02.09.2022

Opus 16

2018/31/D/ST4/01467

NMR structural studies of 8-17 and I-R2 DNAzymes

Witold Andrałojć

02.09.2019

01.09.2022

Sonata 14

2018/31/N/ST5/03589

Exploring second generation of nucleotide analogues containing phosphoranesulfen- or phosphoraneselenamides as new structural motives

Justyna Gołębiewska

30.08.2019

29.08.2021

Preludium 16

2018/31/B/NZ3/03626

Impact of subcellular localization on the specificity of selected enzymes involved in the biosynthesis and metabolism of bioactive sulfur-containing compounds from Brassicaceae plants

Paweł Bednarek

01.08.2019

31.07.2022

Opus 16

2018/29/B/ST4/01498

Small molecule tools to investigate local microenvironment of proteins

Jacek Kolanowski

01.07.2019

30.06.2022

Opus 15

2018/30/E/NZ1/00729

Inhibition of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa by targeting the enzyme dynamics

Krzysztof  Brzeziński

30.04.2019

29.04.2024

Sonata Bis 8

2018/02/X/NZ5/03028

Rescuing Friedreich’s ataxia phenotype by transcription progression

Julia Misiorek

30.03.2019

29.03.2020

Miniatura 2

2018/29/B/NZ1/00293

Investigation of DNA double-strand break repair mechanisms in microsatellite regions using the CRISPR/Cas system

Marta Olejniczak

14.01.2019

13.01.2022

Opus 15

2018/02/X/ST5/02409

Synthesis of a new type of nucleotide analogues with P-N bond as potential anti-HIV pronucleotides

Joanna Romanowska

04.01.2019

02.01.2020

Miniatura 2

2018/02/X/NZ3/02233

Preliminary characterization of the function of ERD6 membrane protein in glucosinolate transport in Arabidopsis immunity

Marta Pastorczyk-Szlenkier

19.12.2018

18.12.2019

Miniatura 2

2018-02/X/NZ1/01797

Obtaining PR-10 isoforms from Hypericum perforatum, as potential melatonin receptors and mediators of phytohormone signal, and preliminary crystallographic characteristics of their complexes with natural ligands

Joanna Śliwiak

03.12.2018

02.12.2019

Miniatura 2

2018/02/X/NZ8/01334

The origin of the population living in today's Poland in the I-IV century- initial isotope analysis of strontium

Małgorzata Marcinkowska-Swojak

02.11.2018

01.11.2019

Miniatura 2

2017/26/E/NZ3/01004

The characteristic of the regulatory RNAs landscape in glioblastoma multiforme (GBM). Circular RNAs and micro RNA-like molecules as new players in gilomagenesis and GBM progression and their importance for glioblastoma stem cells

Katarzyna Rolle

15.10.2018

14.10.2022

Sonata Bis 7

2018/28/C/NZ1/00497

Pioneering structural and functional studies of miRNA G-quadruplexes

Agnieszka Belter

20.09.2018

19.09.2021

Sonatina 2

2017/27/B/NZ1/01090

Molecular basis of the selective transport fulfieled by plant ABCG proteins

Michał Jasiński

17.09.2018

16.09.2021

Opus 14

2017/26/D/NZ2/01079

Contribution of gene copy number polymorphism to natural variation in response of Arabidopsis thaliana ecotypes to biotic stress

Agnieszka Żmieńko

17.09.2018

16.09.2022

Sonata 13

2017/27/B/NZ1/02201

The study of chitinolytic enzymes, aiming at constructing an artificial chitinosome

Wojciech Rypniewski

03.09.2018

02.09.2022

Opus 14

2017/26/D/NZ1/00887

Mechanisms of human gene expression regulation by uridilation

Zbigniew Warkocki

02.07.2018

01.07.2022

Sonata 13

2017/27/B/NZ1/01416

Changes in the ribosomal protein composition and in the ribosome-associated small noncoding RNAs in Saccharomyces cerevisiae as a response to environmental stress

Kamilla Bąkowska-Żywicka

29.06.2018

28.06.2022

Opus 14

2017/26/D/NZ1/01234

Caged bioluminogenic substrates for a selective molecular imaging of biochemical parameters in cancer

Jacek Kolanowski

05.06.2018

04.06.2022

Sonata 13

2017/26/E/NZ1/00950

Development of methodology aiming at stabilisation of RNA in a hairpin form for crystallographic studies

Agnieszka Kiliszek

04.06.2018

03.06.2023

Sonata Bis 7

2017/25/B/NZ7/02162

Anti-aging properties of 4-N-furfyrylocytosine in age-differentiated eukaryotic cells, budding yeast and mouse model of aging

Eliza Wyszko

17.04.2018

16.04.2022

Opus 13

2017/25/B/NZ3/02173

Functional crostallk between circRNAs and extracellular matrix (ECM) - the importance for glioblastoma stem cells (GSC) and epithelial-mesenchymal transition (EMT) in brain tumors

Katarzyna Rolle

16.04.2018

15.04.2022

Opus 13

2017/26/D/NZ2/00964

Identification of biomolecules released by colorectal cancer cells and detected in serum or/and exosomes

Anna Wojakowska

13.04.2018

12.04.2022

Sonata 13

2017/25/B/ST5/00971

Synthesis and structural studies of oligonucleotides with tRNA anticodon stem-loop sequences containing newly discovered modified nucleosides: ct6A, ms2ct6A, ges2U

Zofia Gdaniec

21.02.2018

20.02.2022

Opus 13

2018/02/X/NZ2/02214

Mutagenesis of biosynthetic pathways for secondary metabolites of Brachypodium distachyon model grass

Karolina Krystkowiak

19.02.2018

18.02.2019

Miniatura 2

2017/25/N/NZ2/00221

Copy number polymorphism of microRNA genes in Arabidopsis thaliana accessions and its impact on the post-transcriptional regulation of their target genes' expression

Anna Samelak-Czajka

14.02.2018

13.08.2021

Preludium 13

2017/01/X/NZ2/01906

Exome analysis of acute myeloid leukemia patients

Luiza Handschuh

09.02.2018

08.02.2019

Miniatura 1

2017/25/B/NZ7/00127

Structural determinants of anticancer properties of G-rich oligonucleotides

Anna Pasternak

30.01.2018

29.01.2022

Opus 13

2017/25/B/NZ1/02269

Cotranscriptional folding of influenza virus RNA in MDCK cells in presence of antisense oligonucleotides. A new method for next-generation sequencing based chemical mapping of RNA structure

Ryszard Kierzek

30.01.2018

29.01.2022

Opus 13

2017/24/C/NZ1/00219

Function of secondary structure of influenza A virus vRNA in ribonucleoproteincomplex during viral life cycle

Elżbieta Lenartowicz

10.11.2017

09.11.2021

Sonatina 1

2017/01/X/ST5/00577

New 3,6,9-trisubstituted 9-H-carbazole derivatives as potential fluorescent probes for the detection of DNA and RNA quadruplexes

Daniel Baranowski

10.10.2017

09.10.2018

Miniatura 1

2017/01/X/ST5/00589

The use of chemically modified RNA quadruplexes in antisense therapy

Dorota Gudanis

10.10.2017

09.10.2018

Miniatura 1

2017/01/X/ST5/00680

Synthesis of novel porphyrin derivatives with potential application in photodynamic therapy (PDT)

Zofia Jahnz-Wechmann

10.10.2017

09.10.2018

Miniatura 1

2016/23/N/ST5/03024

N-Oxide phosphobetaines in new synthetic strategies for P-modified phosphates and polyphospates of natural biomolecules and their analogues

Magdalena Materna

20.09.2017

19.12.2019

Preludium 12

2017/01/X/ST5/00381

Synthesis of new pirymidine nucleoside dimers analogues containing a 1,2,3-triazole linkage of potential application in medicine

Dagmara Baraniak

19.09.2017

18.09.2018

Miniatura 1

2016/23/N/NZ1/02446

Designing a new method for direct identification and absolute quantification of premature transcription termination events, following the example of bacterial riboswitches

Piotr Machtel

13.09.2017

12.09.2020

Preludium 12

2017/01/X/NZ2/00144

Copy number variation of Arabidopsis thaliana MSH2 gene - the structure of duplication, range of polymorphism in natural ecotypes and its impact on the expression of genes involved in DNA mismatch repair pathway

Agnieszka Żmieńko

23.08.2017

22.08.2018

Miniatura 1

2016/23/D/NZ1/02565

How RNA structure governs messenger RNA function? Exploring structural and functional aspects essential for synthesis of p53 protein - a master regulator of vital cellular functions

Leszek Błaszczyk

17.08.2017

16.08.2022

Sonata 12

2016/22/A/NZ2/00184

Analysis of somatic mutations in miRNA and miRNA-biogenesis genes to identify new therapeutic targets and biomarkers of cancer

Piotr Kozłowski

15.05.2017

14.05.2022

Maestro 8

2016/22/E/NZ3/00426

RNA structures and interactions with Gag protein that specify Ty1 RNA functions during retrotransposon replication

Katarzyna Pachulska-Wieczorek

08.05.2017

07.05.2022

Sonata Bis 6

2016/22/E/NZ1/00422

Unknown areas of activity of human ribonuclease Dicer

Anna Kurzyńska-Kokorniak

08.05.2017

07.05.2022

Sonata Bis 6

2016/21/B/ST8/00477

New, multifunctional nanoparticles for combined photothermal and gene silencing cancer therapy

Jan Barciszewski

13.04.2017

12.10.2021

Opus 11

2016/21/N/NZ1/00565

Modified siRNAs, ribozymes and cRISPR/Cas system as strategies for influenza A virus inhibition. Application and comparison of RNA-targeting methods

Julita Piasecka

16.03.2017

15.03.2021

Preludium 11

2016/21/N/NZ1/00564

Catalytic RNS's as a tool for human mitochondrial biotechnology

Paweł Głodowicz

15.03.2017

14.03.2021

Preludium 11

2016/21/N/NZ5/00508

Ekspression of circular RNA in myotonic dystrophy type I - implications to
pathogenesis

Karol Czubak

14.03.2017

13.03.2020

Preludium 11

2016/21/D/NZ5/01906

Bifunctional antisense oligonucleotides - optimization of alternative splicing regulation in cancer cell lines

Jolanta Lisowiec-Wąchnicka

02.03.2017

01.03.2021

Sonata 11

2016/21/D/NZ3/00641

Histone demethylase JMJD3 as an epigenetic regulator in the senescence-associated secretory phenotype and cancer

Patrick Perrigue

17.02.2017

16.11.2020

Sonata 11

2016/21/B/NZ2/03468

Impact of noncoding RNAs on renal cell development and carcinogenesis

Jan Wrzesiński

16.02.2017

15.08.2021

Opus 11

2016/21/B/NZ1/02832

The role of protein factors that bind to the 5'non-coding region of human p53 mRNA in regulation of p53 expression at the translational level

Jerzy Ciesiołka

16.02.2017

15.08.2021

Opus 11

2015/19/B/NZ3/02412

Cytoplasmatic roadblocks in cell fate reprogramming: from players to molecular mechanisms

Rafał Ciosk

30.11.2016

29.11.2020

Opus 10

2016/20/W/ST5/00478

Supramolecular Peptide Organic Frameworks (POFs)

Mariusz Jaskólski

10.11.2016

09.11.2022

Symfonia 4

2015/19/D/NZ5/02183

RAN translation at CAG repeats in spinocerebellar ataxia type 3

Magdalena Jazurek-Ciesiołka

01.09.2016

31.08.2022

Sonata 10

2015/19/N/NZ5/02246

Anticoagulant and antiproliferative properties of novel thrombin binding aptamer analogues

Weronika Kotkowiak

09.08.2016

08.02.2018

Preludium 10

2015/19/N/NZ5/02247

The APOBEC3B deletion - analysis of its role in familial breast cancer predisposition and determination of its consequences on mRNA level

Katarzyna Klonowska

09.08.2016

08.08.2019

Preludium 10

2015/19/B/NZ1/02804

Role of microRNAs in regulation iron metabolism in Friedreich's ataxia

Marek Napierała

14.07.2016

13.04.2020

Opus 10

2014/19/B/NZ2/02453

Identification of CAG repeat-binding proteins and imaging RNA-prorein interacrions in cells

Adam Ciesiołka

20.06.2016

19.06.2021

Opus 10

2015/19/B/NZ1/02803

In vivo and in vitro structure of influenza virus RNA. The structural determinants behind the inhibition of influenza virus proliferation with modified antisense oligonucleotides, siRNAs and small molecule ligands

Elżbieta Kierzek

20.06.2016

19.06.2020

Opus 10

2015/19/B/NZ2/02450

Molecular mechanism of atherosclerosis progression in chronic kidney disease

Magdalena Łuczak

20.06.2016

19.12.2021

Opus 10

2015/19/B/NZ9/03548

The role of membrane transporters in the cytokinin signaling upon Legume- Rhizobia Symbiosis

Michał Jasiński

15.06.2016

14.12.2020

Opus 10

2015/18/M/NZ1/00406

Function of plant secondary metabolites in microbe-induced growth promotion

Paweł Bednarek

13.05.2016

12.10.2020

Harmonia 7

2015/18/E/NZ2/00678

The use of genetic tools in experimental therapy of polyglutamine diseases

Marta Olejniczak

18.04.2016

17.10.2021

Sonata Bis 5

2015/17/N/NZ2/01916

MicroRNA profiling in cellular models of Huntington's disease generated using iPSC technology

Emilia Kozłowska

15.03.2016

14.03.2021

Preludium 9

2015/17/N/NZ3/03626

Structure and function of Glod4 protein

Olga Utyro

14.03.2016

13.03.2020

Preludium 9

2015/17/N/NZ3/03629

Imaging miRNA biogenesis pathway and cellular localization of RNA interference triggers

Martyna Urbanek-Trzeciak

09.03.2016

08.12.2019

Preludium 9

2015/17/B/NZ2/01182

Analysis of the role of BARD1 gene in genetic predisposition to breast cancer -
utilization of unique  strategy of association analysis od founder mutations

Piotr Kozłowski

01.03.2016

31.08.2021

Opus 9

2015 17/B/ST5/01467

Catalytic nucleic acids in of the new generation in the regulation of genetic information

Jan Barciszewski

26.02.2016

25.02.2020

Opus 9

2015/17/B/NZ1/00871

Molecular mechanisms underlying loss of a defensive metabolic pathway in a phylogenet ic clade of plant species closely related to Capsella rubella

Paweł Bednarek

25.02.2016

24.07.2019

Opus 9

2015/17/D/NZ5/03443

Comprehensive analysis of the therapeutic potential of oligonucleotides for the treatment of polyglutamine diseases

Agnieszka Fiszer

25.02.2016

24.02.2021

Sonata 9

2015/17/D/NZ3/03625

Active transport systems as an element that controls the molecular cross-talk between symbionts during arbuscular mycorrhiza formation

Joanna Banasiak

02.02.2016

01.02.2020

Sonata 9

2015/17/D/NZ5/03444

Long term survival and oxidative stress in hyperhomocysteinemia

Marta Sikora

28.01.2016

27.07.2020

Sonata 9

2014/15/B/NZ9/02312

Structural studies ofproteins crucial for tick-mammal-pathogen interactions

Mariusz Jaskólski

27.01.2016

26.01.2020

Opus 9

2015/16/S/NZ1/00086

Degradation pathways of transcripts associated with human diseases the basis of which is the expansion of microsatellite sequences

Karolina Drążkowska

01.12.2015

11.03.2019

Fuga 4

2014/15/N/NZ5/01646

Role of hyperhomocysteinemia in scent signalling in mice

Jacek Wróblewski

25.08.2015

24.08.2019

Preludium 8

2014/15/N/NZ5/01647

Pathophysiological consequences of histone N-homocysteinylation in hyperhomocysteinemia caused by CBS deficiency

Izabela Bielińska / Lewandowska

25.08.2015

24.08.2019

Preludium 8

2014/15/D/NZ2/02305

Identification of circular RNAs and protein factors involved in their biogenesis in a model plant, Arabidopsis thaliana

Anna Philips

21.07.2015

20.07.2019

Sonata 8

2014/15/B/NZ9/02312

Identification of molecular mechanisms involved in soybean's cold stress response in temperate climate conditions

Tomasz Twardowski

17.07.2015

16.01.2020

Opus 8

2014/15/B/NZ1/01880

Mechanisms underlying the targeting ofcoding sequence repeats by microRNA-like
inhibitors

Agnieszka Fiszer

15.07.2015

14.07.2019

Opus 8

2014/13/B/NZ5/03214

Understanding the mechanism of action for small molecule kinase inhibitors in
alleviating myotonic dystrophy type I (DMl) pathomechanism

Marzena Wojciechowska

11.03.2015

10.07.2019

Opus 7

2014/13/B/NZ2/03837

Elucidation of the mechanisms that induce copy number polymorphism of large genome fragments and of the relations between this phenomenon and metabolic gene cluster formation and evolution in plants

Marek Figlerowicz

26.02.2015

25.07.2019

Opus 7

2014/13/B/NZ7/02291

Kinetin riboside and its derivatives-analysis of apoptotic properties and mechanism of action in brain tumor cells

Eliza Wyszko

23.01.2015

22.10.2019

Opus 7

2014/13/B/ST5/04144

RNA hybrid duplex-quadruplex structures with dual functionality as a new tool for silecing of gene expression

Zofia Gdaniec

23.01.2015

22.07.2018

Opus 7

2014/13/D/NZ1/00061

Changes in the ribosomal protein composition and in the ribosome-associated small noncoding RNAs in Saccharomyces cerevisiae as a response to environmental stress

Kamilla Bąkowska-Żywicka

22.01.2015

21.01.2018

Sonata 7

2014/12/W/NZ2/00466

Dynasty and population of the Piast State in view of the integrated historical, anthropological and genomic studies

Marek Figlerowicz

10.12.2014

09.12.2021

Symfonia 2

2013/11/B/NZ1/00091

Mechanisms and consequences of homocysteine ​​incorporation into proteins in humans

Hieronim Jakubowski

28.07.2014

27.07.2017

Opus 6

2013/10/E/NZ4/00621

Defining new neurodegeneration mechanisms using the first SCA3/MJD knock-in mouse model

Maciej Figiel

08.07.2014

07.07.2020

Sonata Bis 3

2013/11/N/NZ1/92429

Key elements of miRNA precursors conditioning the release of homogeneous siRNAs from shRNA-miR vectors

Paulina Gałka-Marciniak

04.07.2014

03.07.2016

Preludium 6

2013/10/E/NZ1/00741

Thermodynamic insights into design of functionally optimized modified siRNAs and their experimental verification

Anna Pasternak

02.07.2014

01.04.2018

Sonata Bis 3

2913/10/M/NZ3/00260

ABA transport in legumes - between drought stress responses and nitrogen fixation efficiency

Michał Jasiński

19.05.2014

18.11.2017

Harmonia 5

2013/09/D/NZ1/03364

Evolutionary modeling physicochemical conditions for overexpression of viral replicons in plant liquid cultures

Radosław Pilarski

03.04.2014

02.04.2018

Sonata 5

2013/09/N/NZ2/02080

Evolution of Brassicaceae plant secondary metabolites essential in plant immunity

Karolina Kułak

14.03.2014

13.09.2016

Preludium 5

2013/09/B/NZ1/03359

Ribozymes as a new tool for mitochondrial genome research

Jan Barciszewski

11.03.2014

10.03.2017

Opus 5

2013/09/B/NZ1/01884

The role of the 5' non-coding regions of p53 mRNA transcripts, which are synthesized from various transcription promoters and use alternative initiation sites in generating p53 protein isoforms

Jerzy Ciesiołka

13.02.2014

12.08.2017

Opus 5

2013/09/B/NZ5/02794

Role of  homocysteine in pathogenesis of thrombosis

Hieronim Jakubowski

13.02.2014

12.02.2017

Opus 5

2013/08/T/NZ4/00712

Molecular and behavioral characteristics of new mouse types of cerebellospinal ataxia type 3 (SCA3)

Paweł Świtoński

01.10.2013

30.09.2014

Etiuda 1

2013/08/M/NZ1/01062

Conserved RNA structural motifs in influenza virus: toward revealing viral RNA functions

Elżbieta Kierzek

28.08.2013

27.05.2017

Harmonia 4

2013/08/A/ST5/00295

Structure defined oligonucleotides for revealing fundamental insights into structure and function of RNAs

Ryszard Kierzek

28.08.2013

27.08.2019

Maestro 4

2012/07/B/ST6/01537

Study of the possibilities and limitations of the use of Petri nets for modeling and analysis of complex biological systems on the example of the process of formation and development of atherosclerosis in the human body

Piotr Formanowicz

25.07.2013

24.07.2017

Opus 4

2012/07/B/ST5/03035

Development of chemical method for synthesis of biologically active triphosphates using thermolabile protecting groups

Marcin K.Chmielewski

19.07.2013

18.07.2017

Opus 4

2012/07/E/NZ2/04098

Plant secondary metabolites controlling microbial colonizers

Paweł Bednarek

11.07.2013

10.10.2018

Sonata Bis 2

2012/06/A/NZ9/00125

Multilevel approach to reveal elucive molecular basis of herbicide stress response in maize

Tomasz Twardowski

07.05.2013

06.11.2019

Maestro 3

2012/05/N/NZ7/02157

Study of the relationship between the chemical structure and the activity of new flavonoid derivatives as inhibitors of bacterial tyrosyl tRNA synthetase

Mirosława Skupińska

27.03.2013

26.03.2015

Preludium 4

2012/06/A/NZ1/00094

RNA toxicity in pathogenesis of polyglutamine diseases

Maciej Figiel

22.03.2013

21.03.2019

Maestro 3

2012/05/N/NZ1/0191918.03.2013

The study of structure of miR21 RNA and its precursor - the basis marker of brain tumors in human

Agnieszka Belter

18.03.2013

17.03.2015

Preludium 3

2012/05/D/NZ2/02238

Analysis of the plasma proteome in chronic kidney disease in the context of progressive cardiovascular disease

Magdalena Łuczak

01.03.2013

30.09.2016

Opus 4

2012/05/D/NZ2/02238

Establishment of a novel scientific workshop enabling complex analysis of RNA degradome - elaboration of innovative methods for the identification of RNA degradants and the assessment of their functional potential

Paulina Jackowiak

01.03.2013

31.08.2016

Sonata 3

2012/05/D/ST5/03599

New 3,8-disubstituted purine nucleoside analogues as prospective application for research of structure and biological activity of nucleic acids

Anna Pasternak

07.02.2013

06.02.2016

Sonata 1

2011/03/B/ST5/01098

New approaches towards modulating selective and functional activities of antisense oligonucleotides

Ryszard Kierzek

29.08.2012

28.05.2015

Opus 2

2011/03/B/ST5/03102

Development of stereospecific phosphorylating agents containing nucleophilic catalytic groups

Michał Sobkowski

29.08.2012

28.02.2016

Opus 2

2011/03/B/NZ1/01238

Structural proteomics of mulberry silkworm hemolymph

Grzegorz Bujacz

27.08.2012

26.08.2015

Opus 2

2011/03/B/NZ1/03259

Sequential preferences of ribonucleases of the human microRNA biogenesis pathway

Włodzimierz Krzyżosiak

17.08.2012

16.08.2015

Opus 2

2011/03/B/NZ1/02840

ABC transporters as modulators of Medicago truncatula symbiotic interactions

Michał Jasiński

16.08.2012

15.08.2015

Opus 2

2011/03/B/NZ1/00576

New methods for the determination of RNA secondary structure, tools towards studies biological activities of RNAs

Ryszard Kierzek

02.08.2012

01.08.2015

Opus 2

2011/01/B/NZ4/04936

The new generation of anti-cancer pro-nucleotides

Jacek Stawiński

16.12.2011

15.12.2015

Opus 1

2011/01/N/NZ9/02900

Searching for sequences regulating the splicing process under herbicidal stress in common maize

Joanna Gracz-Bernaciak

16.12.2011

15.10.2014

Preludium 1

2011/01/D/NZ9/03631

Analysis of the epigenome and proteome of maize (Zea mays), a line resistant and sensitive to herbicide

Agata Tyczewska

12.12.2011

11.12.2015

Sonata 1

2011/01/B/ST6/07021

High-performance calculations for next-generation DNA sequencing

Aleksandra Świercz

08.12.2011

07.12.2013

Opus 1

2011/01/B/NZ2/04816

Copy number polymorphism as an important mechanism conditioning the variability of plant genomes. Impact of endogenous (RNA interference) and exogenous (stress) factors on the frequency and location of mutations associated with copy number polymorphism

Marek Figlerowicz

07.12.2011

06.06.2015

Opus 1

2011/01/N/NZ3/04602

Study of the secondary structure and function of BC200 RNA in human brain tumors

Patrycja Sosińska-Zawierucha

07.12.2011

06.12.2013

Preludium 1

2011/01/D/NZ1/03478

RNA chaperone activity of HIV-2 Gag and nuclocapsid proteins: implications for the design of the new retroviral inhibitors

Katarzyna Pachulska-Wieczorek

07.12.2011

06.06.2015

Sonata 1

2011/01/B/NZ1/04429

RNA clip forms of importance in biology and pathogenesis. Crystallographic analysis

Wojciech Rypniewski

06.12.2011

05.06.2015

Opus 1

2011/01/N/NZ2/00025

The use of tandem mass spectrometry with collision-induced dissociation techniques for profiling and structural analysis of phenolic secondary metabolites in multicomponent extracts of plant material

Anna Wojakowska

06.12.2011

05.06.2013

Preludium 1

2011/01/B/NZ1/03417

Mechanisms contributing to the development of thrombosis in patients with cystathionine β-synthesis deficiency

Hieronim Jakubowski

06.12.2011

05.12.2014

Opus 1

2011/01/B/NZ5/02773

Identification of new genes that play an important role in the process of cancer in common human cancers

Piotr Kozłowski

06.12.2011

20.02.2012

Opus 1

2011/01/B/ST5/06414

Aryl nucleoside phosphoramidates - a new generation of anti-HIV pronucleotides

Jacek Stawiński

01.12.2011

30.11.2015

Opus 1

N N401 597840

The effect of N-homocysteinylation of histone proteins on epigenetic regulation of human gene expression

Hieronim Jakubowski

27.05.2011

26.05.2013

Supervisory project; call no. 40

N N310 721640

Study of the relationship between the phenolic secondary metabolite profile and the level of expression of the phenylpropanoid pathway genes in narrow-leafed lupine seedlings when assessing resistance to infection by a fungal pathogen

Maciej Stobiecki

23.05.2011

22.05.2014

Supervisory project; call no. 40

N N310 769040

Small non-coding RNA and changes in plant' degradom as the answer mechanism on stress conditions

Tomasz Twardowski

19.05.2011

18.05.2014

Supervisory project; call no. 40

N N301 707040

RNA quadruplexes built from AGG, CGG and UGG trinucleotide repeats

Zofia Gdaniec

06.05.2011

05.08.2014

Supervisory project; call no. 40

N N301 788440

Studies on the functional nature of the RNA structure of influenza virus aimed at inhibiting its multiplication

Elżbieta Kierzek

06.05.2011

05.05.2014

Supervisory project; call no. 40

N N302 633240

Testing of non-specific effects caused by RNA and microRNA interference technology reagents

Marta Olejniczak

06.05.2011

05.01.2015

Supervisory project; call no. 40

N N401 572140

Regulation of Huntingtin gene expression by RNA duplexes

Włodzimierz Krzyżosiak

06.05.2011

05.05.2014

Supervisory project; call no. 40

N N401 572140

Analysis of the interaction of proteins with mutated transcripts of genes involved in TREDs diseases

Marzena Wojciechowska

04.05.2011

03.01.2015

Supervisory project; call no. 40

N N204 430640

Analysis of human plasma fibrinogen N-homocysteinylation by chemical methods and mass spectrometry in the context of cardiovascular diseases

Łukasz Marczak

20.04.2011

19.04.2014

Supervisory project; call no. 40

N N302 434439

104/5000
Analysis of the effect of genetic inactivation of homocysteine metabolizing enzymes thiolactone on the mouse proteome

Hieronim Jakubowski

12.11.2010

11.04.2013

Supervisory project; call no. 39

N N310 309839

Alternative splicing in maize induced by herbicidal stress

Tomasz Twardowski

22.10.2010

21.10.2013

Supervisory project; call no. 39

N N301 392139

Identification of full ABCG Medicago truncatula transporters and initial functional analysis of selected genes involved in response to biotic stress

Michał Jasiński

23.09.2010

22.04.2013

Supervisory project; call no. 39

N N310 043738

Correlation of epigenetic modification of DNA and histone proteins as a mechanism of plant response to herbicidal stress conditions

Tomasz Twardowski

17.05.2010

28.06.2013

Supervisory project; call no. 38

N N301 411238

New enantiomeric forms of hammerhead ribozymes as therapeutic agents

Jan Barciszewski

17.05.2010

16.05.2013

Supervisory project; call no. 38

N N401 595538

Search and analysis of non-coding RNA specific for malignant brain tumors

Katarzyna Rolle

06.05.2010

05.05.2013

Supervisory project; call no. 38

N N301 523038

Validation of microRNA interactions with mRNA in the context of pathogenesis and therapy of some hereditary neurological diseases

Edyta Kościańska

27.04.2010

31.07.2013

Supervisory project; call no. 38

N N302 260938

Modern antisense technologies in myotonic dystrophy therapy

Krzysztof Sobczak

09.04.2010

30.10.2013

Supervisory project; call no. 38

N N401 066338

A new method of global analysis of modified nucleic acid components and its application in clinical diagnosis of cancer

Mirosława Naskręt-Barciszewska

21.02.2010

20.04.2013

Supervisory project; call no. 40

National Centre for Research and Development

Agreement number

Title

 Principal Investigator

Start date

End date

Project type

LIDER/30/0111/L-9/17/NCBR/2018

Mapping of cytosine modifications in nucleic acids using AID/APOBEC enzymes

Lucyna Budźko

01.03.2019

28.02.2022

Lider 9

ERA-NET-E-RARE- 3/III/TreatPolyQ/08/2018

Allele-specific lowering of mutant polyQ proteins as treatment for Huntington disease, spinocerebellar ataxia type 3 and spinocerebellar ataxia type 7

Maciej Figiel

01.09.2018

31.08.2021

E-RARE

ERA-NET-E-RARE- 3/III/SCA-CYP/09/2018

Gene Therapy for Cerebellar Ataxias: restoring cholesterol metabolism by targeting brain cholesterol 24 hydroxylase (CYP46A1)

Maciej Figiel

01.09.2018

31.08.2021

E-RARE

POWR.03.02.00-00-I011/16

The NanoBioTech interdisciplinary doctoral program

Michał Sobkowski

01.04.2018

31.12.2022

POWER

POIR.04.01.02-00-0025/17-00

Polish Microbiome Map

Anna Philips

01.01.2018

31.12.2021

OPSG

POWR.03.02.00-00-I032/16

Partnership-based, interdisciplinary doctoral program in the field of nanotechnology

Michał Sobkowski

01.01.2018

28.02.2022

POWER

CORNET/IZP/22/2/2017

Innovative processing technology of rapeseed products for poultry nutrition

Tomasz Twardowski

01.10.2017

30.09.2019

CORNET

AMR/1/2015

Structure guided design of pan inhibitors of metallo-β-lactamases

Mariusz Jaskólski

03.03.2015

02.03.2019

JPI AMR

STRATEGMED1/233624/5/NCBR/2014

Low molecular weight epigenetic modulators for activation of pluripotency of cells for regenerative medicine purposes

Wojciech T. Markiewicz

01.01.2015

31.12.2019

STRATEGMED - EPICELL

711/L-4/2012

Nucleoside diphosphates - an innovative concept of anti-HIV pro-nucleotides

Joanna Romanowska

01.05.2014

30.04.2018

Lider 4

CORNET/2/15/2013

Innovative protein products from legume seeds grown under sustainable farming conditions for poultry feeding

Tomasz Twardowski

01.01.2014

31.03.2016

CORNET

PBS1/A8/9/2012

Development of an innovative technology for the production of second generation bioethanol from sorghum (Sorghum sp.) And Miscanthus (Miscanthus sp.) Biomass

Marek Figlerowicz

01.10.2012

31.03.2016

Program for Applied Research

PBS1/B9/7/2012

High-performance substrates for the synthesis of solid-phase biomolecules

Marcin K. Chmielewski

01.10.2012

31.12.2015

Program for Applied Research

Ministry of Science and Higher Education

Agreement number

Title

 Principal Investigator

Start date

End date

Project type

0043/DIA/2020/49

Investigation of initial pathways of DRPLA pathogenesis in human neural precursors

Bartosz Nowak

18.11.2020

17.11.2022

Diamond Grant

DIR/WK/2018/06

European Infrastructure of Open Screening Platforms for Chemical Biology European Research Infrastructure Consortium

Marek Figlerowicz

24.10.2018

31.05.2023

EU-OPENSCREEN

IP2012 049272

Structural aspects of the dimerization process of the Ty1 eukaryotic retrotransposone

Katarzyna Purzycka

01.07.2013

30.12.2015

Iuventus Plus

IP2012 045072

In search of effective therapy for type 1 myotonic dystrophy. Crystallographic analysis of CUG repeat complexes with potential drugs

Agnieszka Kiliszek

25.06.2013

29.01.2016

Iuventus Plus

IP2012 032472

Chemically modified oligonucleotides as potential therapeutics for polyglutamine diseases

Agnieszka Fiszer

18.06.2013

17.09.2015

Iuventus Plus

IP2012 014972

Identification of proteins binding potential regulatory RNAs that are stable transient degradation products

Paulina Jackowiak

14.06.2013

13.12.2015

Iuventus Plus

DI 2011 0278 41

Molecular mechanisms conditioning selective inhibition of mutated genes causing polyglutamine disease

Anna Stroynowska-Czerwińska

27.06.2012

30.09.2015

Diamond Grant

IP2011039771

Area of the leader HIV-2 RNA as a center of synergistic and competitive interaction of Tat-2 and NCp8 viral proteins

Katarzyna Pachulska-Wieczorek

06.04.2012

05.04.2014

Iuventus Plus

0087/PO1/2010/70

The use of catalytic RNA (ribozymes) to inactivate HIV-1

Agnieszka Fedoruk-Wyszomirska

22.12.2010

31.12.2011

Iuventus Plus

Foundation for Polish Science

Agreement number

Title

 Principal Investigator

Start date

End date

Project type

POIR.04.04.00-00-441F/17-00

MultiGATE: dual-analyte responsive fluorescent probes for a real-time multi-parametric sensing in cellular models

Jacek Kolanowski

01.07.2018

28.09.2021

HOMING

POIR.04.04.00-00-203A/16-00

Regulation of body fat: from novel mechanisms to therapeutic targets

Rafał Ciosk

01.10.2017

28.03.2021

TEAM

8./2014

Engineering a "chitinosome"- a toolbox for chitin degradation

Wojciech Rypniewski

01.01.2015

31.12.2017

MISTRZ

POMOST/2013-8/5

Genome- wide RNA secondary structure mapping of coxsackievirus B3

Mariola Dutkiewicz

01.02.2014

31.12.2015

POMOST

HOMING PLUS/2012-6/12

How RNA structure governs Ty1 retrotransposition

Katarzyna Purzycka

01.04.2013

31.03.2015

HOMING PLUS

HOMING PLUS/2012-6/15

Expression of p53 protein and its N-truncated form, deltaNp53 - towards better understanding the mechanism of p53 IRES-mediated translation process

Agata Świątkowska

01.04.2013

31.03.2014

HOMING PLUS

POMOST/2011-4/1

Reavealing an unknown function of tRNA-derived small RNAs is Saccharomyces cerevisiae

Kamilla Bąkowska-Żywicka

01.04.2012

31.03.2015

POMOST

POMOST/2011-3/5

Apta-miRs: novel strategy for controlling miRNA’s biogenesis and functioning

Anna Kurzyńska-Kokorniak

01.11.2011

31.01.2015

POMOST

National Information Processing Institute

Agreement number

Title

 Principal Investigator

Start date

End date

Project type

POIR.04.02.00-00-C004/19-00

NEBI - National Center for Imaging Research in Biological and Biomedical Sciences

Marek Figlerowicz

01.01.2020

31.12.2023

OPSG

POIR.04.02.00-30-A004/16-00

ECBG - European Center for Bioinformatics and Genomics (Genomic Map of Poland)

Marek Figlerowicz

01.12.2016

30.06.2022

OPSG

POIG.01.03.02-00-020/12

Patent protection for a preparation with human AID enzymatic activity

Marek Figlerowicz

01.01.2013

30.06.2015

OPIE

POIG.01.03.02-00-036/11

Patent protection for RNA oligomers regulating biogenesis and microRNA function

Marek Figlerowicz

01.01.2013

30.06.2015

OPIE

POIG.01.03.02-00-037/11

Patent protection for Lyme disease vaccine

Marek Figlerowicz

01.10.2012

30.06.2015

OPIE

POIG.01.03.02-00-060/10

Patent protection of a peptide with Dicer-type RNAse and an innovative method of generating short RNA molecules with the properties of gene expression regulators using this peptide

Marek Figlerowicz

01.11.2010

30.09.2015

OPIE

POIG.01.03.02-00-053/10

Patent protection for a new generation of non-toxic pronucleotide anti-HIV drugs

Adam Kraszewski

01.10.2010

30.09.2015

OPIE

POIG.01.03.01-30-049/09

Experimental cell therapy platform using induced pluripotent stem cells (iPS)

Maciej Figiel

01.04.2010

30.06.2015

OPIE

POIG.01.03.02-30-073/10

Patent protection for the method of obtaining a cytosine analogue with potential anti-cancer properties

Wojciech T. Markiewicz

01.01.2010

30.09.2015

OPIE

POIG.01.03.02-30-016/10

Patent protection of methods for sequencing elements of combinatorial oligonucleotide libraries and/or oligonucleotide analogues

Wojciech T. Markiewicz

01.01.2010

30.09.2015

OPIE

Polish National Agency for Academic Exchange

Agreement number

Title

 Principal Investigator

Start date

End date

Project type

PPN/PPO/2019/1/00035/U/1

Deciphering networks of regulatory RNAs in the central nervous system

Monika Piwecka

05.11.2019

04.11.2023

Polish Returns

PPI/WTP/2019/1/00055/U/00001

Increasing competence and preparing a comprehensive offer of services and support for students and international staff at ICHB PAN

Miłosz Ruszkowski

01.10.2019

30.09.2021

Welcome to Poland

European Commission

Agreement number

Title

 Principal Investigator

Start date

End date

Project type

NUMBER 820431 - LIFE-TIME

Revolutionizing Healtcare by Tracking and Understanding Human Cells during Diseace

Jacek Kolanowski

01.03.2019

30.04.2020

Horyzont 2020

NUMBER 823893-EU-OPENSCREEN-DRIVE

Ensuring long-term sustainability of excellence in chemical biology within Europe and beyond

Jacek Kolanowski

01.02.2019

31.01.2023

Horyzont 2020

European Molecular Biology Organization

Agreement number

Title

 Principal Investigator

Start date

End date

Project type

 

Cell fate plasticity in animal development and tissue homeostasis

Rafał Ciosk

02.10.2017

01.10.2020

Installation Grant

 

Secondary metabolites in plant-microbe interactions

Paweł Bednarek

10.12.2010

14.12.2015

Installation Grant

Other

Agreement number

Title

 Principal Investigator

Start date

End date

Project type

 Funding institution

RPWP.02.01.01-30-0001/20

REGIONAL COVID-HUB

Marek Figlerowicz

01.07.2020

30.06.2022

Wielkopolska Regional Operational Program

Marshal's Office of the Greater Poland Voivodeship

 

Allele selective, CAG-targeted RNAi-based strategy to lower mutant polyQ proteins in polyglutamine ataxias

Maciej Figiel

01.03.2020

01.07.2021

 

National Ataxia Foundation

ICGEB ID#:S/INDl5-05

Structural and thermodynamic consequences ofepigenetic modifications in RNA: the role ofm6A and pseudouridine

Indrajit Deb

01.11.2015

31.10.2016

Arturo Falachi ICGEB Fellowship Programme

International Centre for Genetic Engineering and Biotechnology

List of grants running in the Institute since 2010