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Institute of Bioorganic Chemistry,
Polish Academy of Sciences
Z. Noskowskiego 12/14
61-704 Poznań
tel centrala: (+48) 61 852 85 03
fax: (+48) 61 852 05 32
e-mail: ibch@ibch.poznan.pl

Sekretariat Dyrektora, tel: 61 852 89 19

Address

Department of RNA Biochemistry

Prof. Jerzy Ciesiołka

Head of Department:
jerzy.ciesiolka@ibch.poznan.pl
ext. 1198

Dr. habil. Jan Wrzesiński

associate professor

Dr. Agata Świątkowska

adiunkt

Dr. Damian Janecki

asystent

Dr. Paulina Żydowicz-Machtel

asystent

Researchers:

Research Projects

Martyna Kabacińska MSc

specjalista biolog

Dr. habil. Mariola Dutkiewicz

adiunkt

Technical Staff:

Joanna Szpotkowska MSc

asystent

Marek  Kazimierczyk MSc

PhD student

PhD students:

  • mRNA,
  • p53,
  • non-coding RNA region,
  • UTR,
  • translation regulation,
  • IRES-dependent translation,
  • coxsackievirus B3,
  • CVB-3,
  • antisense oligonucleotides,
  • siRNA,
  • renal cells, 
    non-coding RNA,
  • cellular interactions of non-coding RNAs

Research area

Keywords

  • Structural and functional analysis of sequence variants of the 5' non-coding region of p53 mRNA: characterization of the structure of this region and its role in the translation process; elucidating the role of different p53 protein isoforms synthesized in the cell; identification and characterization of proteins interacting with the 5' non-coding region of p53 mRNA.

  • Coxsackie B3 virus research: searching for highly conserved RNA structural elements in the CVB3 virus genome and their structural and functional analysis; development of a rational strategy for attacking viral RNA using oligonucleotide tools; virus-cell interactions.

  • Application of embryonic and mature kidney cells as a model of cultured human stem cells to understand the different stages of development of this organ: analysis of the expression of non-coding RNAs using new sequencing methods; characterization of the interaction of various molecules with long non-coding RNAs in human cells.

 

  • Swiatkowska, M. Dutkiewicz, P. Machtel, D. Janecki, M. Kabacinska, P. Żydowicz-Machtel, J. Ciesiołka. Regulation of the p53 expression profile by hnRNP K under stress conditions. RNA Biology, doi: 10.1080/15476286.2020.1771944 (2020) 

  • M. Kazimierczyk, M. K. Kasprowicz, M. E. Kasprzyk, J. Wrzesinski. Human Long Noncoding RNA Interactome: Detection, Characterization and Function. Int J Mol Sci. 21, 1027 (2020) 

  • Swiatkowska, M. Dutkiewicz, P. Zydowicz-Machtel, J. Szpotkowska, D. M. Janecki, J. Ciesiołka. Translational Control in p53 Expression: The Role of 5'-Terminal Region of p53 mRNA. Int J Mol Sci, 20, 5382 (2019)

  • M. Kazimierczyk, A. Jędroszkowiak, D. Kowalczykiewicz, M. Szymanski, B. Imiołczyk, J. Ciesiołka, J. Wrzesinski. tRNA-derived fragments from the Sus scrofa tissues provide evidence of their conserved role in mammalian development. Biochem Biophys Res Comm, 520, 514-519 (2019) 

  • J. Szpotkowska, A. Swiatkowska, J. Ciesiołka. Length and secondary structure of the 5′ non-coding regions of mouse p53 mRNA transcripts - mouse as a model organism for p53 gene expression studies. RNA Biology, 16, 25-41 (2019) 

  • M. Dutkiewicz, J. Ciesiołka. Form confers function: The case of the 3'X region of the hepatitis C virus genome. World Journal of Gastroenterology, 24(30), 3374-3383 (2018) 

  • P. Zydowicz-Machtel, A. Swiatkowska, Ł. Popenda, A. Gorska, and J. Ciesiołka. Variants of the 5′-terminal region of p53 mRNA influence the ribosomal scanning and translation efficiency. Scientific Reports, 8, 1533 (2018)

  • A. Kasprowicz, K. Stokowa-Sołtys, M. Jeżowska-Bojczuk, J. Wrzesiński, and J. Ciesiołka. Characterization of highly efficient RNA-cleaving DNAzymes that function at an acidic pH with no divalent metal ion cofactors. ChemistryOpen, 6, 46-56 (2017)

  • A. Kasprowicz, K. Stokowa-Sołtys, J. Wrzesiński, M. Jeżowska-Bojczuk, and J. Ciesiołka. In vitro selection of deoxyribozymes active with Cd2+ ions resulting in variants of DNAzyme 8-17. Dalton Transactions, 44, 8138-8149 (2015)

  • A. Swiątkowska, P. Żydowicz, A. Górska, J. Suchacka, M. Dutkiewicz, and J. Ciesiołka. The role of structural elements of the 5′-terminal region of p53 mRNA in translation under stress conditions assayed by the antisense oligonucleotide approach. PLOS ONE, 10, e0141676 (2015)

  • M. Dutkiewicz, A. Ojdowska, J. Kuczyński, V. Lindig, H. Zeichhardt, J. Kurreck, J. Ciesiołka. Targeting Highly Structured RNA by Cooperative Action of siRNAs and Helper Antisense Oligomers in Living Cells. PLOS ONE, 10, e0136395 (2015)

Selected publications

  • The role of protein factors that bind to the 5' non-coding region of human p53 mRNA in regulation of p53 expression at the translational level. NSC – OPUS 11

  • Impact of noncoding RNAs on renal cell development and carcinogenesis. NSC – OPUS 11
     

Research activity