Prof. Jerzy Ciesiołka
Head of Department:
jerzy.ciesiolka@ibch.poznan.pl
ext. 1198
Dr. habil. Jan Wrzesiński
associate professor
Dr. Agata Świątkowska
adiunkt
Dr. Paulina Żydowicz-Machtel
asystent
Dr. Damian Janecki
asystent
Dr. habil. Mariola Dutkiewicz
starszy specjalista biolog
Martyna Kabacińska MSc
specjalista biolog
Joanna Szpotkowska MSc
asystent
Marek Kazimierczyk MSc
PhD student
Structural and functional analysis of sequence variants of the 5' non-coding region of p53 mRNA: characterization of the structure of this region and its role in the translation process; elucidating the role of different p53 protein isoforms synthesized in the cell; identification and characterization of proteins interacting with the 5' non-coding region of p53 mRNA.
Coxsackie B3 virus research: searching for highly conserved RNA structural elements in the CVB3 virus genome and their structural and functional analysis; development of a rational strategy for attacking viral RNA using oligonucleotide tools; virus-cell interactions.
Application of embryonic and mature kidney cells as a model of cultured human stem cells to understand the different stages of development of this organ: analysis of the expression of non-coding RNAs using new sequencing methods; characterization of the interaction of various molecules with long non-coding RNAs in human cells.
Swiatkowska, M. Dutkiewicz, P. Machtel, D. Janecki, M. Kabacinska, P. Żydowicz-Machtel, J. Ciesiołka. Regulation of the p53 expression profile by hnRNP K under stress conditions. RNA Biology, doi: 10.1080/15476286.2020.1771944 (2020)
M. Kazimierczyk, M. K. Kasprowicz, M. E. Kasprzyk, J. Wrzesinski. Human Long Noncoding RNA Interactome: Detection, Characterization and Function. Int J Mol Sci. 21, 1027 (2020)
Swiatkowska, M. Dutkiewicz, P. Zydowicz-Machtel, J. Szpotkowska, D. M. Janecki, J. Ciesiołka. Translational Control in p53 Expression: The Role of 5'-Terminal Region of p53 mRNA. Int J Mol Sci, 20, 5382 (2019)
M. Kazimierczyk, A. Jędroszkowiak, D. Kowalczykiewicz, M. Szymanski, B. Imiołczyk, J. Ciesiołka, J. Wrzesinski. tRNA-derived fragments from the Sus scrofa tissues provide evidence of their conserved role in mammalian development. Biochem Biophys Res Comm, 520, 514-519 (2019)
J. Szpotkowska, A. Swiatkowska, J. Ciesiołka. Length and secondary structure of the 5′ non-coding regions of mouse p53 mRNA transcripts - mouse as a model organism for p53 gene expression studies. RNA Biology, 16, 25-41 (2019)
M. Dutkiewicz, J. Ciesiołka. Form confers function: The case of the 3'X region of the hepatitis C virus genome. World Journal of Gastroenterology, 24(30), 3374-3383 (2018)
P. Zydowicz-Machtel, A. Swiatkowska, Ł. Popenda, A. Gorska, and J. Ciesiołka. Variants of the 5′-terminal region of p53 mRNA influence the ribosomal scanning and translation efficiency. Scientific Reports, 8, 1533 (2018)
A. Kasprowicz, K. Stokowa-Sołtys, M. Jeżowska-Bojczuk, J. Wrzesiński, and J. Ciesiołka. Characterization of highly efficient RNA-cleaving DNAzymes that function at an acidic pH with no divalent metal ion cofactors. ChemistryOpen, 6, 46-56 (2017)
A. Kasprowicz, K. Stokowa-Sołtys, J. Wrzesiński, M. Jeżowska-Bojczuk, and J. Ciesiołka. In vitro selection of deoxyribozymes active with Cd2+ ions resulting in variants of DNAzyme 8-17. Dalton Transactions, 44, 8138-8149 (2015)
A. Swiątkowska, P. Żydowicz, A. Górska, J. Suchacka, M. Dutkiewicz, and J. Ciesiołka. The role of structural elements of the 5′-terminal region of p53 mRNA in translation under stress conditions assayed by the antisense oligonucleotide approach. PLOS ONE, 10, e0141676 (2015)
M. Dutkiewicz, A. Ojdowska, J. Kuczyński, V. Lindig, H. Zeichhardt, J. Kurreck, J. Ciesiołka. Targeting Highly Structured RNA by Cooperative Action of siRNAs and Helper Antisense Oligomers in Living Cells. PLOS ONE, 10, e0136395 (2015)
The role of protein factors that bind to the 5' non-coding region of human p53 mRNA in regulation of p53 expression at the translational level. NSC – OPUS 11
Impact of noncoding RNAs on renal cell development and carcinogenesis. NSC – OPUS 11
Strona zrobiona w kreatorze stron internetowych WebWave
Institute of Bioorganic Chemistry,
Polish Academy of Sciences
Z. Noskowskiego 12/14
61-704 Poznań
tel centrala: (+48) 61 852 85 03
fax: (+48) 61 852 05 32
e-mail: ibch@ibch.poznan.pl
Sekretariat Dyrektora, tel: 61 852 89 19