• osiągnięcia badawcze

Osiągnięcia badawcze

Department of Ribonucleoprotein Biochemistry

Dr. habil. Anna Kurzyńska-Kokorniak, associate professor

Head of Department
akurzyns@ibch.poznan.pl
ext. 1264

Agnieszka Szczepańska Msc, BEng.

PhD student

Marta Wojnicka MSc, BEng.

PhD student

Kinga Ciechanowska MSc

PhD student/biologist

PhD students:

  • Pokornowska M, Milewski MC, Ciechanowska K, Szczepańska A, Wojnicka M, Radogostowicz Z, Figlerowicz M, Kurzynska-Kokorniak A*. The RNA-RNA base pairing potential of human Dicer and Ago2 proteins. Cell Mol Life Sci. 2020; 77(16):3231-3244. doi: 10.1007/s00018-019-03344-6.

  • Wojnicka M, Szczepanska A, Kurzynska-Kokorniak A*. Unknown Areas of Activity of  Human Ribonuclease Dicer: A Putative Deoxyribonuclease Activity. Molecules. 2020; 25(6):1414. doi: 10.3390/molecules25061414.

  • Milewski MC, Kamel K, Kurzynska-Kokorniak A, Chmielewski MK, Figlerowicz M. EvOligo – a novel software to design and group libraries of oligonucleotides applicable for nucleic acid-based experiments. J Comput Biol. 2017; 24(10):1014-1028. doi: 10.1089/cmb.2016.0154.

  • Mickiewicz A, Sarzyńska J, Miłostan M, Kurzynska-Kokorniak A, Rybarczyk A, Łukasiak P, Kuliński T, Figlerowicz M, Błażewicz J. Modeling of the catalytic core of Arabidopsis thaliana Dicer-like 4 protein and its complex with double-stranded RNA. Comput Biol Chem. 2017; 66:44-56. doi: 10.1016/j.compbiolchem.2016.11.003.

  • Kurzynska-Kokorniak A*, Pokornowska M, Koralewska N, Hoffmann W, Bienkowska-Szewczyk K, Figlerowicz M. Revealing a new activity of the human Dicer DUF283 domain in vitro. Sci Rep. 2016; 6:23989. doi: 10.1038/srep23989.

  • Koralewska N, Hoffmann W, Pokornowska M, Milewski M, Lipinska A, Bienkowska-Szewczyk K, Figlerowicz M, Kurzynska-Kokorniak A*. How short RNAs impact the human ribonuclease Dicer activity: putative regulatory feedback-loops and other RNA-mediated mechanisms controlling microRNA processing. Acta Biochim Pol. 2016; 63(4):773-783. doi: 10.18388/abp.2016_1339.

  • Tworak A, Urbanowicz A, Podkowinski J, Kurzynska-Kokorniak A, Koralewska N, Figlerowicz M. Six Medicago truncatula Dicer-like protein genes are expressed in plant cells and upregulated in nodules. Plant Cell Rep. 2016; 35(5):1043-52. doi: 10.1007/s00299-016-1936-8.

  • Kurzynska-Kokorniak A, Koralewska N, Pokornowska M, Urbanowicz A, Tworak A, Mickiewicz A, Figlerowicz M. The many faces of Dicer: the complexity of the mechanisms regulating Dicer gene expression and enzyme activities. Nucleic Acids Res. 2015; 43(9):4365-80. doi: 10.1093/nar/gkv328.

Selected publications

  • nucleic acid binding proteins,
  • Dicer-type ribonucleases,
  • regulatory RNAs,
  • RNA-protein interactions, DNA-protein interactions,
  • regulation of activity of Dicer-type ribonucleases,
  • regulation of gene expression.

Research area

Keywords:

  • the role of RNA/ DNA in the activity and functions of nucleic acid binding proteins,

  • mechanisms involved in the regulation of gene expression,

  • ribonuclease Dicer variants (gene, transcript, protein),

  • endogenous factors regulating activity of ribonuclease Dicer,

  • designing and testing of inhibitors against Dicer-type ribonucleases,

  • the activity of Dicer-type ribonucleases in the context of viral infections, viral miRNAs,

  • unknown areas of activity of Dicer-type ribonucleases: ribonuclease Dicer as a nucleic acid chaperone,

  • diseases linked to malfunction of Dicer.

Research Projects

Unknown areas of activity of human ribonuclease Dicer. NSC – SONATA BIS 6

Research activity

Media Społecznościowe

Strona zrobiona w kreatorze stron internetowych WebWave

Cooperation

Institute of Bioorganic Chemistry,
Polish Academy of Sciences
Z. Noskowskiego 12/14
61-704 Poznań
tel centrala: (+48) 61 852 85 03
fax: (+48) 61 852 05 32
e-mail: ibch@ibch.poznan.pl

Sekretariat Dyrektora, tel: 61 852 89 19

Adress