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Institute of Bioorganic Chemistry,
Polish Academy of Sciences
Z. Noskowskiego 12/14
61-704 Poznań
tel centrala: (+48) 61 852 85 03
fax: (+48) 61 852 05 32
e-mail: ibch@ibch.poznan.pl
Sekretariat Dyrektora, tel: 61 852 89 19
Dr. habil. Anna Kurzyńska-Kokorniak, associate professor
Head of Department
akurzyns@ibch.poznan.pl
ext. 1264
Agnieszka Szczepańska Msc, BEng.
PhD student
Marta Wojnicka MSc, BEng.
PhD student
Kinga Ciechanowska MSc
PhD student/biologist
Koralewska N, Szczepanska A, Ciechanowska K, Wojnicka M, Pokornowska M, Milewski MC, Gudanis D, Baranowski D, Nithin C, Bujnicki JM, Gdaniec Z, Figlerowicz M, Kurzynska-Kokorniak A*. RNA and DNA G-quadruplexes bind to human dicer and inhibit its activity. Cell Mol Life Sci. 2021; doi: 10.1007/s00018-021-03795-w.
Ciechanowska K, Pokornowska M, Kurzyńska-Kokorniak A*. Genetic Insight into the Domain Structure and Functions of Dicer-Type Ribonucleases. Int J Mol Sci. 2021; 22(2):616. doi: 10.3390/ijms22020616.
Pokornowska M, Milewski MC, Ciechanowska K, Szczepańska A, Wojnicka M, Radogostowicz Z, Figlerowicz M, Kurzynska-Kokorniak A*. The RNA-RNA base pairing potential of human Dicer and Ago2 proteins. Cell Mol Life Sci. 2020; 77(16):3231-3244. doi: 10.1007/s00018-019-03344-6.
Wojnicka M, Szczepanska A, Kurzynska-Kokorniak A*. Unknown Areas of Activity of Human Ribonuclease Dicer: A Putative Deoxyribonuclease Activity. Molecules. 2020; 25(6):1414. doi: 10.3390/molecules25061414.
Koralewska N, Ciechanowska K, Pokornowska M, Figlerowicz M, Kurzyńska-Kokorniak A*. Human ribonuclease Dicer – structure and functions. Postepy Biochem. 2019; 65(3):173-182. doi: 10.18388/pb.2019_267.
Milewski MC, Kamel K, Kurzynska-Kokorniak A, Chmielewski MK, Figlerowicz M. EvOligo – a novel software to design and group libraries of oligonucleotides applicable for nucleic acid-based experiments. J Comput Biol. 2017; 24(10):1014-1028. doi: 10.1089/cmb.2016.0154.
Mickiewicz A, Sarzyńska J, Miłostan M, Kurzynska-Kokorniak A, Rybarczyk A, Łukasiak P, Kuliński T, Figlerowicz M, Błażewicz J. Modeling of the catalytic core of Arabidopsis thaliana Dicer-like 4 protein and its complex with double-stranded RNA. Comput Biol Chem. 2017; 66:44-56. doi: 10.1016/j.compbiolchem.2016.11.003.
Kurzynska-Kokorniak A*, Pokornowska M, Koralewska N, Hoffmann W, Bienkowska-Szewczyk K, Figlerowicz M. Revealing a new activity of the human Dicer DUF283 domain in vitro. Sci Rep. 2016; 6:23989. doi: 10.1038/srep23989.
Koralewska N, Hoffmann W, Pokornowska M, Milewski M, Lipinska A, Bienkowska-Szewczyk K, Figlerowicz M, Kurzynska-Kokorniak A*. How short RNAs impact the human ribonuclease Dicer activity: putative regulatory feedback-loops and other RNA-mediated mechanisms controlling microRNA processing. Acta Biochim Pol. 2016; 63(4):773-783. doi: 10.18388/abp.2016_1339.
Tworak A, Urbanowicz A, Podkowinski J, Kurzynska-Kokorniak A, Koralewska N, Figlerowicz M. Six Medicago truncatula Dicer-like protein genes are expressed in plant cells and upregulated in nodules. Plant Cell Rep. 2016; 35(5):1043-52. doi: 10.1007/s00299-016-1936-8.
Kurzynska-Kokorniak A, Koralewska N, Pokornowska M, Urbanowicz A, Tworak A, Mickiewicz A, Figlerowicz M. The many faces of Dicer: the complexity of the mechanisms regulating Dicer gene expression and enzyme activities. Nucleic Acids Res. 2015; 43(9):4365-80. doi: 10.1093/nar/gkv328.
the role of RNA/ DNA in the activity and functions of nucleic acid binding proteins,
mechanisms involved in the regulation of gene expression,
ribonuclease Dicer variants (gene, transcript, protein),
endogenous factors regulating activity of ribonuclease Dicer,
designing and testing of inhibitors against Dicer-type ribonucleases,
the activity of Dicer-type ribonucleases in the context of viral infections, viral miRNAs,
unknown areas of activity of Dicer-type ribonucleases: ribonuclease Dicer as a nucleic acid chaperone,
diseases linked to malfunction of Dicer.
Unknown areas of activity of human ribonuclease Dicer. NSC – SONATA BIS 6