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Institute of Bioorganic Chemistry,
Polish Academy of Sciences
Z. Noskowskiego 12/14
61-704 Poznań
tel centrala: (+48) 61 852 85 03
fax: (+48) 61 852 05 32

Sekretariat Dyrektora, tel: 61 852 89 19


Integrative Biology Team

Dr. habil. Rafał Ciosk

Team Leader

ext. 1140

  • Aeschimann F, Kumari P, Bartake H, Gaidatzis D, Ciosk R, and Großhans H.LIN41 post-transcriptionally silences mRNAs by two distinct and position-dependent mechanisms.Mol Cell 65; 476-89 (2017)

  • Habacher C, Guo Y, Venz R, Kumari P, Neagu A, Gaidatzis D, Harvald E, Færgeman N, Gut H, and Ciosk R Ribonuclease-mediated control of body fat.Dev Cell 39,359-369 (2016)

  • Fassnacht C and Ciosk RCell fate maintenance and reprogramming during the oocyte-to-embryo transition.In the Springer series Results and Problems in Cell Differentiation 59, 269-86 (2017)

  • Habacher C and Ciosk RZC3H12A/MCPIP1/Regnase-1-related endonucleases: An evolutionary perspective on molecular mechanisms and biological functions.BioEssays 39 (2017)

  • Seelk S, Kalchhauser I, Hargitai B, Hajduskova M, Gutnik S, Tursun B, and Ciosk RIncreasing Notch signaling antagonizes PRC2-mediated silencing to promote reprogramming of germ cells into neurons.eLife 5:e15477 (2016).

  • 6. Tocchini C and Ciosk RTRIM-NHL proteins in development and disease.Seminars Cell and Dev Biol 47-8, 52-9 (2015)

Selected publications

  • Cytoplasmic roadblocks in cell fate reprogramming: from players to molecular mechanisms. NSC – OPUS 10

  • Regulation of body fat: from novel mechanisms to therapeutic targets. FPS – TEAM

  • Cell fate plasticity in animal development and tissue homeostasis. EMBO – INSTALLATION GRANT

Research activity

  • Gene regulation,
  • RNA biology,
  • development,
  • pluripotency,
  • metabolism,
  • fat regulation
  • Posttranscriptional gene regulation

  • Cytoplasmic roadblocks to cellular reprograming

  • Regulation of fat metabolism

Research area


Research Projects


Technical Staff:

PhD students:

Dr. habil. Edyta Kościańska


Dr. Weronika Wendlandt-Stanek


Aneta Dyczkowska MSc

PhD student

Alicja Komur M. Eng.

PhD student

Bogna Juskowiak MSc

PhD student

Katarzyna Solka MSc


Dr. Agnieszka Chabowska-Kita


Dr. Jarosław Lewandowski


Dr. Daria Sobańska