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Institute of Bioorganic Chemistry,
Polish Academy of Sciences
Z. Noskowskiego 12/14
61-704 Poznań
tel centrala: (+48) 61 852 85 03
fax: (+48) 61 852 05 32

Sekretariat Dyrektora, tel: 61 852 89 19


Department of Medical Biology

Prof. Mirosława Z. Naskręt-Barciszewska

Head of Department
ext. 1132

Dr. Agnieszka Belter



Technical Staff:

Iwona Gawrońska


  • DNA methylation,

  • human brain tumors ,

  • cancers,

  •  modified nucleosides,

  •  miRNA,

  •  ribozymes,

  • 8-oxoguanosine.

The research activity of the Department focuses on studies of new molecular markers of neoplastic and metabolic diseases as well as developing new therapeutic approaches with nucleic acids and their derivatives.
We are working on:

  • Construction of new ribozymes and DNAzymes for the inhibition of miRNA  (A),

  • Analysis of the secondary structure of miRNAs specific for brain tumors using catalytic RNAs (B),

  • Analysis of the content of 5-methylcytosine in DNA from brain tumors and other human pathologies (C),

  • Assessment of 5-methylcytosine content in DNA from deciduous seeds,

  • Analysis of non-coding RNAs in humans and in plants,

  • Determination of the content of 8-oxoguanosine and m5C in DNA from brain tumors (D),

  • Application of low molecular weight compounds in the therapy of brain tumors.

Research area


Research Projects

  • M. Michalak, M.Z. Barciszewska, J. Barciszewski, B.P. Plitta, P. Chmielarz (2013) Global Changes in DNA Methylation in Seeds and Seedlings of Pyrus communis after Seed Desiccation and Storage. PLoS One 8(8), e70693.

  • A-M. Barciszewska, S. Nowak, M.Z. Naskręt-Barciszewska. (2014)The Degree of Global DNA Hypomethylation in Peripheral Blood Correlates with that in Matched Tumor Tissues in Several neoplasia. PLoS One 9(3), e92599.

  • Belter, D. Gudanis, K. Rolle, M. Piwecka, Z. Gdaniec, MZ. Naskręt-Barciszewska, J. Barciszewski. (2014) Mature miRNAs form secondary structure, which suggests their function beyond RISC. PLoS One 9(11): e113848.

  • M. Doniak , MZ. Barciszewska, J. Kaźmierczak, A. Kaźmierczak. (2015) The crucial elements of the 'last step' of programmed cell death induced by kinetin in root cortex of V. faba ssp. minor seedlings. Plant Cell Rep DOI 10.1007/s00299-014-1681-9.

  • A-M. Barciszewska,D. Gurda, P. Głodowicz, S. Nowak, MZ. Naskręt-Barciszewska (2015) A new epigenetic mechanism of temozolomide action in glioma cells. PloS ONE 10(8):e136669.

  • MZ. Barciszewska, PP Perrigue, J Barciszewski. (2016) tRNA – the golden standard in molecular biology. Molecular BioSystems. 12, 12-17.

  • Belter, K. Rolle, M. Piwecka, M. A. Fedoruk-Wyszomirska, MZ Naskręt-Barciszewska, J.Barciszewski. (2016) Inhibition of miR-21 in glioma cells using catalytic nucleic acids" Scientific Reports. 6:24516.

  • M. Olszewska, MZ. Barciszewska, M. Fraczek, N. Huleyuk, V B. Chernykh, D. Zastavna, J. Barciszewski, M. Kurpisz. (2017) Global methylation status of sperm DNA in carriers of chromosome structural aberrations Asian Journal of Andrology 18, 1-8.

  • K. Rolle, M. Piwecka, A. Belter, D. Wawrzyniak, J. Jeleniewicz, MZ. Barciszewska, J. Barciszewski. (2016) The sequence and structure determine the function of mature human miRNAs. PLoS ONE 11(3): e0151246

  • BP. Plitta-Michalak, M.Z. Naskręt-Barciszewska, S. Kotlarski, D. Tomaszewski, T. Tylkowski, J. Barciszewski, P. Chmielarz, M. Michalak. (2018) Changes in genomic 5-methylcytosine level mirror the response of orthodox (Acer platanoides L.) and recalcitrant (Acer pseudoplatanus L.) seeds to severe desiccation. Tree Physiol  38(4) 617-629. doi: 10.1093/treephys/tpx134

  • AM. Barciszewska, M. Giel-Pietraszuk, PM. Perrigue, M. Naskręt-Barciszewska. (2019) Total DNA methylation changes reflect random oxidative DNA damage in gliomas. Cells 8 1065;doi 10.3390/cells8091065

  • Patrick M. Perrigue *, Magdalena Rakoczy, Kamila Pawlicka, Agnieszka Belter, Małgorzata Giel-Pietraszuk, Mirosława Naskręt-Barciszewska, Jan Barciszewski, Marek Figlerowicz. (2020) Cancer stem cell-inducing media activates senescence reprogramming in fibroblasts. Cancers (Basel). 12(7):E1745. doi: 10.3390/cancers12071745.

  • Belter A, Barciszewski J, Barciszewska AM (2020) Revealing the epigenetic effect of temozolomide on glioblastoma cell lines in therapeutic conditions. PLoS ONE 15(2): e0229534.

Selected publications

  • Pioniering structural and funcional studies of miRNA G-quadruplexes.

Research activity