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Europejskie Centrum Bioinformatyki i Genomiki

Instytut Informatyki Politechniki Poznańskiej

Wielkopolskie Centrum Zaawansowanych Technologii

Institute of Bioorganic Chemistry,
Polish Academy of Sciences
Z. Noskowskiego 12/14
61-704 Poznań
tel centrala: (+48) 61 852 85 03
fax: (+48) 61 852 05 32
e-mail: ibch@ibch.poznan.pl

Sekretariat Dyrektora, tel: 61 852 89 19

Dr. inż. Małgorzata Marcinkowska-Swojak

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Dr. Patrick Perrigue

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Dr. Natalia Koralewska

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Dr. Lucyna Budźko

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Dr. habil. Paulina Jackowiak

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• Philips A, Nowis K, Stelmaszczuk M, Jackowiak P, Podkowiński J, Handschuh L, Figlerowicz M. Expression landscape of circRNAs in Arabidopsis thaliana seedlings and adult tissues. Frontiers in Plant Science 2020, in press

• Philips A , Nowis K, Stelmaszczuk  M , Podkowiński  J, Handschuh  L , Jackowiak  P, Figlerowicz M. Arabidopsis thaliana cbp80, c2h2, and flk knockout mutants accumulate increased amounts of circular RNAs. Cells 2020; 9(9):E1937

• Perrigue PM, Rakoczy M, Pawlicka KP, Belter A, Giel-Pietraszuk M, Naskręt-Barciszewska M, Barciszewski J, Figlerowicz M. Cancer stem cell-inducing media activates senescence reprogramming in fibroblasts. Cancers 2020; 12(7): 1745

• Zmienko A, Marszalek-Zenczak M, Pawel Wojciechowski P, Samelak-Czajka A, Luczak M, Kozlowski P, Karlowski WM, Figlerowicz M.

• AthCNV: A Map of DNA Copy Number Variations in the Arabidopsis Genome. Plant Cell 2020; 32(6): 1797–1819

•  Stolarek I, Handschuh L, Juras A, Nowaczewska W, Kóčka-Krenz H, Michalowski A, Piontek J, Kozlowski P, Figlerowicz M. Goth migration induced changes in the matrilineal genetic structure of the central-east European population. Sci Rep. 2019; 9(1):6737

• Jackowiak P, Lis A, Luczak M, Stolarek I, Figlerowicz M. Functional characterization of RNA fragments using high-throughput interactome screening. J Proteomics. 2019;193:173-183

• Stolarek I, Juras A, Handschuh L, Marcinkowska-Swojak M, Philips A, Zenczak M, Dębski A, Kóčka-Krenz H, Piontek J, Kozlowski P, Figlerowicz M. A mosaic genetic structure of the human population living in the South Baltic region during the Iron Age. Sci Rep. 2018;8(1):2455

• Handschuh L, Wojciechowski P, Kaźmierczak M, Marcinkowska-Swojak M, Łuczak M, Lewandowski K, Komarnicki M, Blazewicz J, Figlerowicz M, Kozlowski P. NPM1 alternative transcripts are upregulated in acute myeloid and lymphoblastic leukemia and their expression level affects patient outcome. J Transl Med. 2018, 16(1):232 

• Handschuh L, Kaźmierczak M, Milewski MC, Góralski M, Łuczak M, Wojtaszewska M, Uszczyńska-Ratajczak B, Lewandowski K, Komarnicki M, Figlerowicz M. Gene expression profiling of acute myeloid leukemia samples from adult patients with AML-M1 and -M2 through boutique microarrays, real-time PCR and droplet digital PCR. Int J Oncol. 2018, 52:656-678

• Handschuh L. Not Only Mutations Matter: Molecular Picture of Acute Myeloid Leukemia Emerging from Transcriptome Studies. Journal of Oncology, 2019, 7239206

• Jackowiak P, Hojka-Osinska A, Gasiorek K, Stelmaszczuk M, Gudanis D, Gdaniec Z, Figlerowicz M. Effects of G-quadruplex topology on translational inhibition by tRNA fragments in mammalian and plant systems in vitro. Int J Biochem Cell Biol. 2017;92:148-154

• Jackowiak P, Hojka-Osinska A, Philips A, Zmienko A, Budzko L, Maillard P, Budkowska A, Figlerowicz M. Small RNA fragments derived from multiple RNA classes - the missing element of multi-omics characteristics of the hepatitis C virus cell culture model. BMC Genomics. 2017;18(1):502

• Budzko L, Jackowiak P, Kamel K, Sarzynska J, Bujnicki JM, Figlerowicz M. Mutations in human AID differentially affect its ability to deaminate cytidine and 5-methylcytidine in ssDNA substrates in vitro. Sci Rep. 2017;7(1):3873

• Philips A, Stolarek I, Kuczkowska B, Juras A, Handschuh L, Piontek J, Kozlowski P, Figlerowicz M. Comprehensive analysis of microorganisms accompanying human archaeological remains. Gigascience. 2017;6(7):1-13

• Samelak-Czajka A, Marszalek-Zenczak M, Marcinkowska-Swojak M, Kozlowski P, Figlerowicz M, Zmienko A. MLPA-Based Analysis of Copy Number Variation in Plant Populations. Front Plant Sci. 2017;8:222

• Zmienko A, Samelak-Czajka A, Kozlowski P, Szymanska M, Figlerowicz M. Arabidopsis thaliana population analysis reveals high plasticity of the genomic region spanning MSH2, AT3G18530 and AT3G18535 genes and provides evidence for NAHR-driven recurrent CNV events occurring in this location. BMC Genomics. 2016;17(1):893

• Marcinkowska-Swojak M, Handschuh L, Wojciechowski P, Goralski M, Tomaszewski K, Kazmierczak M, Lewandowski K, Komarnicki M, Blazewicz J, Figlerowicz M, Kozlowski P. Simultaneous detection of mutations and copy number variation of NPM1 in the acute myeloid leukemia using multiplex ligation-dependent probe amplification. Mutat Res. 2016;786:14-26

• Perrigue PM, Najbauer J, Barciszewski J. The histone demethylase JMJD3 at the intersection of cellular senescence and cancer. BBA Rev on Cancer 2016;1865(2):237-244

• Perrigue PM, Najbauer J, Jozwiak AA, Barciszewski J, Aboody KS, Barish ME. Planarians as a model of aging to study the interaction between stem cells and senescent cells in vivo. Pathobiol Aging Age Relat Dis. 2015;5:30052

• Kurzynska-Kokorniak A, Koralewska N, Pokornowska M, Urbanowicz A, Tworak A, Mickiewicz A, Figlerowicz M. The many faces of Dicer: the complexity of the mechanisms regulating Dicer gene expression and enzyme activities. Nucleic Acids Res. 2015;43(9):4365-80

• Zmienko A, Samelak A, Kozlowski P, Figlerowicz M. Copy number polymorphism in plant genomes. Theor Appl Genet. 2014;127(1):1-18

• Kurzynska-Kokorniak A1, Koralewska N, Tyczewska A, Twardowski T, Figlerowicz M. A New Short Oligonucleotide-Based Strategy for the Precursor-Specific Regulation of microRNA Processing by Dicer. PLoS One. 2013 Oct 29;8(10):e77703

• Jackowiak P, Nowacka M, Strozycki PM, Figlerowicz M. RNA degradome – its biogenesis and functions. Nucleic Acids Res. 2011;39(17):7361-70

• RPWP.02.01.01-30-0001/20 REGIONAL COVID-HUB. WROP 2014-2020 2.1 Development of electronic public services Sub-measure 2.1.1 Development of electronic public services

• 2019/35/B/NZ2/02658 Comprehensive analysis of the Schmidtea mediterranea transcriptome – identification of non-coding RNAs involved in cell lineage development during regeneration. NCN OPUS 18

• LIDER/30/0111/L-9/17NCBR/2018 Mapping of cytosine modifications in nucleic acids using AID/APOBEC enzymes. NCBR LIDER 9

• POIR.04.01.02-00-0025/17-00 Polish Microbiome Map. SG OP Measure 4.1. Research and development Sub-measure 4.1.2 Regional research agendas 

• POIR.04.02.00-30-A004/16 European Centre of Bioinformatics and Genomics – Polish Genome Project. SG OP Measure 4.2. Development of modern research infrastructure in the science sector

• 820431 LifeTime – Revolutionizing Healthcare by Tracking and Understanding Human Cells During Disease. European Commission 

• 2016/21/D/NZ3/00641 Histone demethylase JMJD3 as an epigenetic regulator in the senescence-associated secretory phenotype and cancer. NCN SONATA 11

• 2014/13/B/NZ2/03837 Elucidation of the mechanisms that induce copy number polymorphism of large genome fragments and of the relations between this phenomenon and metabolic gene cluster formation and evolution in plants. NCN OPUS 7

• 2014/12/W/NZ2/00466 Dynasty and population of the Piast State in view of the integrated historical, anthropological and genomic studies. NCN SYMFONIA 2

• Polish Infrastructure of Screening Platform for Biological Chemistry Project (POL-OPENSCREEN), a part of the European Infrastructure of Open Screening Platforms for Chemical Biology European Research Infrastructure Consortium(EU-OPENSCREEN ERIC). Polish Ministry of Science and Higher Education

Prof. Marek Figlerowicz

Head of Department
marek.figlerowicz@ibch.poznan.pl
ext.1103

Karolina Hoffa-Sobiech MSc Eng.

biolog

Marcin Osuch MSc

biolog

Dr. Magdalena Alejska

starszy specjalista biolog

Dr. Ireneusz Stolarek

adiunkt

Przy Zakładzie afiliowana jest:

Pracownia Genomiki

Kierownik: dr Luiza Handschuh

dr Jan Podkowiński, dr Paweł Wojciechowski (1/2 etatu), dr Agnieszka Żmieńko

Pracownia Hodowli Komórkowych i Tkankowych

Kierownik: dr Paweł Stróżycki

Hanna Glapiak, inż. Nelli Malinowska, dr Mariola Piślewska-Bednarek

Katarzyna Nowis MSc

PhD student

Cezary Odrzygóźdź MSc BEng.

PhD student / biologist

Małgorzata Marszałek-Zeńczak MSc

PhD student / biologist

Anastasiia Satyr MSc

PhD student

Michał Zeńczak MSc BEng.

PhD student

non-coding RNA, RNA modifications, ribonucleases, extracellular vesicles, RNA transport, deaminases, chromatin, genomics, population genetics, archaeogenomics
 

• RNA as a regulator of differentiation and regeneration
• Non-coding RNAs as molecular signals
• Ribonucleases involved in the metabolism of non-coding RNA 
• Biogenesis and functioning of extracellular vesicles 
• Proteins participating in the intercellular transport of RNA 
• RNA editing in regulation and signaling 

• Archaeogenomics – the biological history of the populations living in Central and Eastern Europe
• Genetic variability of the modern population  of Poland
• Relation between genotype and physical characteristics of the individual
• Chromatin structure in aging, cancer, and regeneration
• Genomics in the research of human diseases

mgr Anastasiia Zaremba
PhD student

Annasha Dutta MSc
PhD student