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Institute of Bioorganic Chemistry,
Polish Academy of Sciences
Z. Noskowskiego 12/14
61-704 Poznań
tel centrala: (+48) 61 852 85 03
fax: (+48) 61 852 05 32
e-mail: ibch@ibch.poznan.pl

Sekretariat Dyrektora, tel: 61 852 89 19

Address

Department of Biopolymers Chemistry

Dr. habil. Marcin K. Chmielewski

Head of Department
chmielewskimk@ibch.poznan.pl
ext.1257

Magdalena Paluch MSc

PhD student

Anna Stasińska MSc

PhD student

PhD students:

Dominika Krygier MSc, BEng

specialist chemist

Technical Staff:

Dr. Jolanta Brzezińska
adiunkt

Researchers:

  • Brzezinska, J., Witkowska, A., Kaczyński, T.P., Krygier, D., Ratajczak, T., and Chmielewski, M.K.. 2-Pyridinyl thermolabile groups as general protectants for hydroxyl, phosphate, and carboxyl functions.  Curr. Protoc. Nucleic Acid Chem. 68, 2.20.1-2.20.25 (2017).doi: 10.1002/cpnc.26

  • Milewski Marek C., Kamel Karol, Kurzynska-Kokorniak Anna, Chmielewski Marcin K., and Figlerowicz Marek EvOligo: A Novel Software to Design and Group Libraries of Oligonucleotides Applicable for Nucleic Acid-Based Experiments Journal of Computational Biology. 24, 1-15 (2017), ahead of print. doi:10.1089/cmb.2016.0154.

  • Szubert K., Piepiórka M., Jankowska-Wajda M., Brzezinska J., Pasternak K., Remszel N., Frydrych-Tomczak E., Maciejewski H., Chmielewski M. K. Amino-functional Silsesquioxanes (POSS) – Effective Glass Surface Modifiers in Solid-Phase Nucleic Acid Synthesis Current Organic Chemistry 21, 1-8, (2017) DOI: 10.2174/1385272821666170222111024

  •  Chmielewski M.K., P. Kaczyński T.P. Methods for nucleoside triphosphate preparation: an overview of the most recent synthetic approaches Mini-Reviews in Organic Chemistry 14, 6 (2017) DOI: 10.2174/1570193X14666170420113635

  • Czaja, K, Kujawski, J, Jodlowska-Siewert, E, Szulc, P, Ratajczak, T, Krygier, D, Chmielewski, M.K., Bernard, M.K. On the Interactions of Fused Pyrazole Derivative with Selected Amino Acids: DFT Calculations (2017) Journal of Chemistry, vol. 2017, Article ID 8124323, 9 pages, doi:10.1155/2017/8124323

  • Kuciński, K.; Jankowska-Wajda, M.; Ratajczak, T.; Bałabańska-Trybuś, S.; Anna Schumann, A.; Maciejewski, H.; Chmielewski, M.K.; Hreczycho, G. Silica Surface Modification and Its Application in Permanent Link with Nucleic Acids ACS Omega, 3 (6), 5931–5937 (2018) https://doi.org/10.1021/acsomega.8b00547

  • Brzezinska J, Kujawski J, Witkowska A, Czaja K, Bernard M.K., Chmielewski, M.K. Experimental and computational studies on a protonated 2-pyridinyl moiety and its switchable effect for the design of thermolytic devices. PLoS ONE 13(9), (2018) e0203604. https://doi.org/10.1371/journal.pone.0203604

  • Stasińska A.R., Putaj P., Chmielewski M.K. Disulfide bridge as a linker in nucleic acids’ bioconjugation. Part I: An overview of synthetic strategies Bioorganic Chemistry 92, 103223, (2019) (10.1016/j.bioorg.2019.103223)

  • Agnieszka Witkowska A., Brzezinska J., Pedzinski T., Chmielewski M.K. Fluorescent 2-(Pyridin-2-yl)vinyl Pyridine Dyes and Their Thermocontrolled Release J. Org. Chem., 84, 13447-13456 (2019) DOI: doi.org/10.1021/acs.joc.9b01620

  • Anna R. Stasińska, Piotr Putaj, Marcin K. Chmielewski, Disulfide bridge as a linker in nucleic acids’ bioconjugation. Part II: a summary of practical applications, Bioorganic Chemistry 95, 103518, (2020), https://doi.org/10.1016/j.bioorg.2019.103518.

  •  Hyjek-Składanowska, M., Stasińska, A. R., Napiórkowska, A., Bartłomiejczak, A., Seth, P. P., Chmielewski, M. K., & Nowotny, M. (2020). Disulfide bridge cross-linking between protein and the RNA backbone as a tool to study RNase H1. Bioorganic & Medicinal Chemistry, 115741. doi:10.1016/j.bmc.2020.115741 

Selected publications

  • High-efficiency resins for solid-phase synthesis of biomolecules. NCRD – PBS1

  • Development of method of chemical synthesis of bio-active triphosphates using thermolabile protecting. NSC – OPUS 4

  • Synthesis and characterization of novel functional organic silicon compounds as silica functionalising agent. NSC – OPUS 5

  • Thermolytic fluorescent dyes in nucleic acid labelling. co-funded by the European POIR.01.01.01-00-0027/17-00. 01.10.2017 – 30.09.2020 head of the project

  • “Regulated Assembly of Molecular Machines for DNA Repair: a Molecular Analysis Network” (DNARepairMan) as part of Innovative Training network supported through EU Horizon 2020 Marie Sklodowska-Curie Action under project number H2020-MSCA-ITN-2016 [DNAREPAIRMAN - 722433]. 31.01.2017-30.01.2020 project executive

Research activity

  • protecting groups,
  • thermolabile protecting groups,
  • nucleic acids synthesis,
  • DNA, RNA, modifications,
  • thermosensitivity,
  • thermolability,
  • cross-linking,
  • fluorescent labels,
  • fluorescent dyes,
  • fluorescence,
  • infra-red,
  • FRET,
  • quencher,
  • polymers,
  • biopolymers,
  • aptamers,
  • functional groups,
  • nanostructures,
  • nanomachines,
  • nanodevices,
  • catalysis,
  • solid-phase,
  • markers,
  • larg-scale synthesis,
  • polystyren,
  • HPLC,
  • capillary electrophoresis,
  • PVA
  • research in chemical synthesis of biopolymers such as nucleic acids, peptides, carbohydrates and lipids. 

  • application of original  thermocyclization reaction in wider aspect of chemical synthesis. 

  • Thermolability as tools in design of protecting groups, fluorescent labels, thermo-dependent catalysts and in polymerization reactions.

  • investigate in chemistry of examined compounds, to define the mechanism of observed processes and to obtain useful materials applicable in area of Life Sciences. 

  • instrumental analysis  using PVA capillary electrophoresis, High Pressure Liquid Chromatography (HPLC) with UV-Vis, fluorescence and korona detectors.

Research area

Keywords

Research Projects