Department of Biopolymers Chemistry

Dr. habil. Marcin K. Chmielewski

Head of Department
chmielewskimk@ibch.poznan.pl
ext.1257

Magdalena Paluch MSc

PhD student

Anna Stasińska MSc

PhD student

PhD students:

Dominika Krygier MSc, BEng

specialist chemist

Technical Staff:

Dr. Jolanta Brzezińska
adiunkt

Researchers:

  • Mickiewicz, A.; Sarzyńska, J.; Miłostan, M.; Kurzyńska-Kokorniak, A.; Rybarczyk, A.; Łukasiak, P.; Kuliński, T.; Figlerowicz, M.; Błażewicz, J.Modeling of the catalytic core of Arabidopsis thaliana Dicer-like 4 protein and its complex with double-stranded RNA.Comput. Biol. Chem. 66, 44–56 (2017),

  • Baranek, Małgorzata; Belter, Agnieszka; Naskręt-Barciszewska, Mirosława Z.; Stobiecki, Maciej; Markiewicz, Wojciech T.; Barciszewski, Jan,Effect of small molecules on cell reprogramming.Mol. BioSyst. 13, 277–313 (2017),

  • Stokowa-Sołtys, K.; Barbosa, N. A.; Kasprowicz, A.; Wieczorek, R.; Gaggelli, N.; Gaggelli, E.; Valensin, G.; Wrzesiński, J.; Ciesiołka, J.; Kuliński, T.; Szczepanik, W.; Jeżowska-Bojczuk, M. Studies of viomycin, an anti-tuberculosis antibiotic: copper(II) coordination, DNA degradation and the impact on delta ribozyme cleavage activity.Dalt. Trans. 45, 8645–8658 (2016),

  • Fedoruk-Wyszomirska, A.; Markiewicz, W. T.; Barciszewski, J.New inhibitors of DNA methyltransferase 1 based on cytosine scaffold.BioTechnologia 4, 323–325 (2016),

  • Baranek, M.; Markiewicz, W. T.; Barciszewski, J.Selected small molecules as inducers of pluripotency.Acta Biochim. Pol. 63, 709–716 (2016),

  • Rypniewski, W.; Banaszak, K.; Kuliński, T.; Kiliszek, A.Watson–Crick-like pairs in CCUG repeats: evidence for tautomeric shifts or protonation.RNA, 22, 22–31 (2016),

  • Brzezinska, J.; Markiewicz, W. T.Non-Nucleosidic Analogues of Polyaminonucleosides and Their Influence on Thermodynamic Properties of Derived Oligonucleotides.Molecules 20, 12652–12669 (2015),

  • Barciszewski, J.; Marquez, V. E.; Vasseur, J.-J.; Markiewicz, W. T.Chemical Biology of Nucleic Acids.ACS Chem. Biol. 10, 1358–1361 (2015),

  • Mickiewicz, A.; Sarzyńska, J.; Miłostan, M.; Kurzyńska-Kokorniak, A.; Rybarczyk, A.; Łukasiak, P.; Kuliński, T.; Figlerowicz, M.; Błażewicz, J.Modeling of the catalytic core of Arabidopsis thaliana Dicer-like 4 protein and its complex with double-stranded RNA.Comput. Biol. Chem. 66, 44–56 (2017)

Selected publications

  • High-efficiency resins for solid-phase synthesis of biomolecules. NCRD – PBS1

  • Development of method of chemical synthesis of bio-active triphosphates using thermolabile protecting. NSC – OPUS 4

  • Synthesis and characterization of novel functional organic silicon compounds as silica functionalising agent. NSC – OPUS 5

  • Thermolytic fluorescent dyes in nucleic acid labelling. co-funded by the European POIR.01.01.01-00-0027/17-00. 01.10.2017 – 30.09.2020 head of the project

  • “Regulated Assembly of Molecular Machines for DNA Repair: a Molecular Analysis Network” (DNARepairMan) as part of Innovative Training network supported through EU Horizon 2020 Marie Sklodowska-Curie Action under project number H2020-MSCA-ITN-2016 [DNAREPAIRMAN - 722433]. 31.01.2017-30.01.2020 project executive

Research activity

  • protecting groups,
  • thermolabile protecting groups,
  • nucleic acids synthesis,
  • DNA, RNA, modifications,
  • thermosensitivity,
  • thermolability,
  • cross-linking,
  • fluorescent labels,
  • fluorescent dyes,
  • fluorescence,
  • infra-red,
  • FRET,
  • quencher,
  • polymers,
  • biopolymers,
  • aptamers,
  • functional groups,
  • nanostructures,
  • nanomachines,
  • nanodevices,
  • catalysis,
  • solid-phase,
  • markers,
  • larg-scale synthesis,
  • polystyren,
  • HPLC,
  • capillary electrophoresis,
  • PVA
  • research in chemical synthesis of biopolymers such as nucleic acids, peptides, carbohydrates and lipids. 

  • application of original  thermocyclization reaction in wider aspect of chemical synthesis. 

  • Thermolability as tools in design of protecting groups, fluorescent labels, thermo-dependent catalysts and in polymerization reactions.

  • investigate in chemistry of examined compounds, to define the mechanism of observed processes and to obtain useful materials applicable in area of Life Sciences. 

  • instrumental analysis  using PVA capillary electrophoresis, High Pressure Liquid Chromatography (HPLC) with UV-Vis, fluorescence and korona detectors.

Research area

Keywords

Research Projects

Media Społecznościowe

Strona zrobiona w kreatorze stron internetowych WebWave

Cooperation

Institute of Bioorganic Chemistry,
Polish Academy of Sciences
Z. Noskowskiego 12/14
61-704 Poznań
tel centrala: (+48) 61 852 85 03
fax: (+48) 61 852 05 32
e-mail: ibch@ibch.poznan.pl

Sekretariat Dyrektora, tel: 61 852 89 19

Adress