Department of Biopolymers Chemistry

Dr. habil. Marcin K. Chmielewski

Head of Department
chmielewskimk@ibch.poznan.pl
ext.1257

Magdalena Paluch MSc

PhD student

Anna Stasińska MSc

PhD student

Dominika Krygier MSc, BEng

specialist chemist

Dr. Jolanta Brzezińska
adiunkt

• Mickiewicz, A.; Sarzyńska, J.; Miłostan, M.; Kurzyńska-Kokorniak, A.; Rybarczyk, A.; Łukasiak, P.; Kuliński, T.; Figlerowicz, M.; Błażewicz, J.Modeling of the catalytic core of Arabidopsis thaliana Dicer-like 4 protein and its complex with double-stranded RNA.Comput. Biol. Chem. 66, 44–56 (2017),

• Baranek, Małgorzata; Belter, Agnieszka; Naskręt-Barciszewska, Mirosława Z.; Stobiecki, Maciej; Markiewicz, Wojciech T.; Barciszewski, Jan,Effect of small molecules on cell reprogramming.Mol. BioSyst. 13, 277–313 (2017),

• Stokowa-Sołtys, K.; Barbosa, N. A.; Kasprowicz, A.; Wieczorek, R.; Gaggelli, N.; Gaggelli, E.; Valensin, G.; Wrzesiński, J.; Ciesiołka, J.; Kuliński, T.; Szczepanik, W.; Jeżowska-Bojczuk, M. Studies of viomycin, an anti-tuberculosis antibiotic: copper(II) coordination, DNA degradation and the impact on delta ribozyme cleavage activity.Dalt. Trans. 45, 8645–8658 (2016),

• Fedoruk-Wyszomirska, A.; Markiewicz, W. T.; Barciszewski, J.New inhibitors of DNA methyltransferase 1 based on cytosine scaffold.BioTechnologia 4, 323–325 (2016),

• Baranek, M.; Markiewicz, W. T.; Barciszewski, J.Selected small molecules as inducers of pluripotency.Acta Biochim. Pol. 63, 709–716 (2016),

• Rypniewski, W.; Banaszak, K.; Kuliński, T.; Kiliszek, A.Watson–Crick-like pairs in CCUG repeats: evidence for tautomeric shifts or protonation.RNA, 22, 22–31 (2016),

• Brzezinska, J.; Markiewicz, W. T.Non-Nucleosidic Analogues of Polyaminonucleosides and Their Influence on Thermodynamic Properties of Derived Oligonucleotides.Molecules 20, 12652–12669 (2015),

• Barciszewski, J.; Marquez, V. E.; Vasseur, J.-J.; Markiewicz, W. T.Chemical Biology of Nucleic Acids.ACS Chem. Biol. 10, 1358–1361 (2015),

• Mickiewicz, A.; Sarzyńska, J.; Miłostan, M.; Kurzyńska-Kokorniak, A.; Rybarczyk, A.; Łukasiak, P.; Kuliński, T.; Figlerowicz, M.; Błażewicz, J.Modeling of the catalytic core of Arabidopsis thaliana Dicer-like 4 protein and its complex with double-stranded RNA.Comput. Biol. Chem. 66, 44–56 (2017)

• High-efficiency resins for solid-phase synthesis of biomolecules. NCRD – PBS1

• Development of method of chemical synthesis of bio-active triphosphates using thermolabile protecting. NSC – OPUS 4

• Synthesis and characterization of novel functional organic silicon compounds as silica functionalising agent. NSC – OPUS 5

• Thermolytic fluorescent dyes in nucleic acid labelling. co-funded by the European POIR.01.01.01-00-0027/17-00. 01.10.2017 – 30.09.2020 head of the project

• “Regulated Assembly of Molecular Machines for DNA Repair: a Molecular Analysis Network” (DNARepairMan) as part of Innovative Training network supported through EU Horizon 2020 Marie Sklodowska-Curie Action under project number H2020-MSCA-ITN-2016 [DNAREPAIRMAN - 722433]. 31.01.2017-30.01.2020 project executive

• protecting groups,
• thermolabile protecting groups,
• nucleic acids synthesis,
• DNA, RNA, modifications,
• thermosensitivity,
• thermolability,
• cross-linking,
• fluorescent labels,
• fluorescent dyes,
• fluorescence,
• infra-red,
• FRET,
• quencher,
• polymers,
• biopolymers,
• aptamers,
• functional groups,
• nanostructures,
• nanomachines,
• nanodevices,
• catalysis,
• solid-phase,
• markers,
• larg-scale synthesis,
• polystyren,
• HPLC,
• capillary electrophoresis,
• PVA

• research in chemical synthesis of biopolymers such as nucleic acids, peptides, carbohydrates and lipids. 

• application of original  thermocyclization reaction in wider aspect of chemical synthesis. 

• Thermolability as tools in design of protecting groups, fluorescent labels, thermo-dependent catalysts and in polymerization reactions.

• investigate in chemistry of examined compounds, to define the mechanism of observed processes and to obtain useful materials applicable in area of Life Sciences. 

• instrumental analysis  using PVA capillary electrophoresis, High Pressure Liquid Chromatography (HPLC) with UV-Vis, fluorescence and korona detectors.

Strona zrobiona w kreatorze stron internetowych WebWave

Europejskie Centrum Bioinformatyki i Genomiki

Instytut Informatyki Politechniki Poznańskiej

Wielkopolskie Centrum Zaawansowanych Technologii

Institute of Bioorganic Chemistry,
Polish Academy of Sciences
Z. Noskowskiego 12/14
61-704 Poznań
tel centrala: (+48) 61 852 85 03
fax: (+48) 61 852 05 32
e-mail: ibch@ibch.poznan.pl

Sekretariat Dyrektora, tel: 61 852 89 19