Dr. habil. Michał Sobkowski
Head of Department
msob@ibch.poznan.pl
ext. 1182
Dr. Grzegorz Framski
starszy specjalista chemik
Dr. Dagmara Baraniak
adiunkt
Dr. habil. Tomasz Ostrowski
profesor instytutu
Dr. Joanna Romanowska
adiunkt
Justyna Gołębiewska MSc
asystent
Prof. Jerzy Boryski
professor
Prof. Adam Kraszewski
professor
Prof. Jacek Stawiński
professor
J. Golebiewska, J. Stawinski: „Reaction of Boranephosphonate Diesters with Pyridines or Tertiary Amines in the Presence of Iodine: Synthetic and Mechanistic Studies”, J. Org. Chem., 85, 4312-4323, 2020.
J. Romanowska, K. Kolodziej, M. Sobkowski, M. Rachwalak, T. Jakubowski, J. Golebiewska, A. Kraszewski, J. Boryski, A. Dabrowska, J. Stawinski: „Aryl H-phosphonates. 19. New anti-HIV pronucleotide phosphoramidate diesters containing amino- and hydroxypyridine auxiliaries”. Eur.J.Med.Chem. 164:47-58, 2019.
J. Golebiewska, M. Rachwalak, T. Jakubowski, J. Romanowska, J. Stawinski: „Reaction of Boranephosphonate Diesters with Amines in the Presence of Iodine: The Case for the Intermediacy of H-Phosphonate Derivatives”, J. Org. Chem., 83, 5496-5505, 2018.
Szymanska-Michalak, D. Wawrzyniak, G. Framski, J. Stawinski, J. Barciszewski, A. Kraszewski: „New antiglioma zwitterionic pronucleotides with an FdUMP framework”, Eur. J. Med. Chem., 144, 682-691, 2018.
M. Materna, J. Stawinski, A. Kiliszek, W. Rypniewski, M. Sobkowski: „Oxyonium phosphobetaines - unusually stable nucleophilic catalyst-phosphate complexes formed from H-phosphonates and N-oxides”, RSC Adv., 6, 14448-14451, 2016.
Z. Jahnz-Wechmann, G. Framski, P. Januszczyk, J. Boryski: „Bioactive fused heterocycles: Nucleoside analogs with an additional ring”. Eur. J. Med. Chem. 97, 388-396, 2015.
M. Sobkowski, A. Kraszewski, J. Stawinski: „Recent Advances in H-Phosphonate Chemistry. Part 1. H-Phosphonate Esters: Synthesis and Basic Reactions”, „Part 2. Synthesis of C-Phosphonate Derivatives”, Topics in Current Chemistry, 137-177 & 179-216, 2015.
J. Romanowska, M. Sobkowski, A. Szymanska-Michalak, K. Kolodziej, A. Dabrowska, A. Lipniacki, A. Piasek, Z. M. Pietrusiewicz, M. Figlerowicz, A. Guranowski, J. Boryski, J. Stawinski, A. Kraszewski: „Aryl H-phosphonates 17: (N-Aryl)phosphoramidates of pyrimidine nucleoside analogues and their synthesis, selected properties, and anti-HIV activity”, J. Med. Chem. 54, 6482-6491, 2011.
M. Sobkowski. „Chemistry and stereochemistry of internucleotide bond formation by the H-phosphonate method”, New J. Chem. 34, 854-869, 2010.
J. Boryski: „Reactions of Transglycosylation in the Nucleoside Chemistry”, Current Organic Chemistry, 12, 309-325, 2008.
G. Framski, Z. Gdaniec, M. Gdaniec, J. Boryski: „A reinvestigated mechanism of ribosylation of adenine under silylating conditions”. Tetrahedron, 62, 10123-10129, 2006.
J. Boryski: „Regioselectivity and Mechanism of Transpurination Reactions in the Guanine Nucleosides Series”. J. Chem. Soc., Perkin Trans. 2, 649-652, 1997.
J. Jankowska, M. Sobkowski, J. Stawinski, A. Kraszewski: „Studies on aryl H-phosphonates. 1. An efficient method for the preparation of deoxyribo- and ribonucleoside 3'-H-phosphonate monoesters by transesterification of diphenyl H-phosphonate”, Tetrahedron Lett. 35, 3355-3358, 1994.
J. Stawinski, A. Kraszewski: „How to get the most out of two phosphorus chemistries. Studies on H-phosphonates”, Acc.Chem.Res., 35, 952–960, 2002.
J. Boryski, B. Golankiewicz, E. De Clercq: „Synthesis and Antiviral Activity of Novel N-Substituted Derivatives of Acyclovir”. J. Med. Chem., 31, 1351-1355, 1988.
P.J. Garegg, I. Lindh, T. Regberg, J. Stawinski, R. Stromberg, C. Henrichson: „Nucleoside H-phosphonates. III. Chemical synthesis of oligonucleotides by the hydrogenphosphonate approach”. Tetrahedron Lett. 27, 4051-4054, 1986.
R. Crea, A. Kraszewski, T. Hirose, K. Itakura: „Chemical synthesis of genes for human insulin”, Proc. Natl. Acad. Sci. USA, 75, 5765–5769, 1978.
K.J. Marians, R. Wu, J. Stawinski, T. Hozumi, S.A. Narang: „Cloned synthetic lac operator DNA is biologically active”, Nature, 263, 744–748, 1976.
Chemical architecture of fluorinated nucleoside dimers containing 1,2,3-triazole linker of potential use in molecular biology and medicine. SONATA 15 (2019/35/D/NZ7/03637), PI: Dagmara Baraniak, PhD
Exploring second generation of nucleotide analogues containing phosphoranesulfen- or phosphoraneselenamides as new structural motives. PRELUDIUM 16 (2018/31/N/ST5/03589), PI: Justyna Gołębiewska, MSc
Chemistry of nucleotides
basic research on the methods of synthesis, chemical and physicochemical properties of H-phosphonates with particular emphasis on nucleoside H-phosphonates and their analogues
design and synthesis of new nucleotide compounds (e.g., pronucleotides) with potential antiviral (e.g., anti-HIV) or anti-tumor activity
studies on metabolic pathways of pronucleotides in various chemical and physiological environments
chemistry and stereochemistry of P-chiral nucleotide analogues
intramolecular catalysis in the stereospecific synthesis of internucleotide bonds
Chemistry of nucleosides
search for new approaches towards synthesis of nucleobases and nucleosides (controlled degradation, rearrangements)
synthesis and characterization of nucleoside analogues of potential biological activity, mainly ring analogs of pyrimidine and purine, 7-regioiomers of purine nucleosides, acyclonucleosides, 2’-C-alkylribofuranosides, and analogs od dinucleoside monophosphates, in which internucleotide bond has been replaced with triazole moiety
synthesis and biological activity of analogs of dinucleoside monophosphates, in which internucleotide bond has been replaced with 1,2,3-triazole moiety
study on the mechanism and applications of transglycosylation reactions
Tomasz Modrzyński MSc. BEng.
doktorant
Strona zrobiona w kreatorze stron internetowych WebWave
Institute of Bioorganic Chemistry,
Polish Academy of Sciences
Z. Noskowskiego 12/14
61-704 Poznań
tel centrala: (+48) 61 852 85 03
fax: (+48) 61 852 05 32
e-mail: ibch@ibch.poznan.pl
Sekretariat Dyrektora, tel: 61 852 89 19