Strona zrobiona w kreatorze stron internetowych WebWave

Europejskie Centrum Bioinformatyki i Genomiki

Instytut Informatyki Politechniki Poznańskiej

Wielkopolskie Centrum Zaawansowanych Technologii

Institute of Bioorganic Chemistry,
Polish Academy of Sciences
Z. Noskowskiego 12/14
61-704 Poznań
tel centrala: (+48) 61 852 85 03
fax: (+48) 61 852 05 32
e-mail: ibch@ibch.poznan.pl

Sekretariat Dyrektora, tel: 61 852 89 19

Department of Crystallography - Center for Biocrystallographic Research

Prof. Mariusz Jaskólski

Head of Department
mariuszj@ibch.poznan.pl
ext. 1245

Wojciech Witek MSc

PhD student

Stanisław Wosicki MSc

PhD student

Ha Linh Tran
 doktorant

Dr. habil. Mirosław Gilski

starszy specjalista chemik

Dr. Barbara Imiołczyk

starszy specjalista biolog

Dr. habil. Dariusz Brzeziński

adiunkt

Dr. Miłosz Ruszkowski

adiunkt

Dr. Kamil Szpotkowski

adiunkt

Dr. Paweł Drożdżal

adiunkt

• A.Wlodawer, Z.Dauter, W.Minor, R.Stanfield, P.Porebski, M.Jaskolski, E.Pozharski, C.X.Weichenberger, B.RuppDetect, Correct, Retract: How to manage incorrect structural models.FEBS J. 1-10 (2017)

• M.Chwastyk, M.Jaskolski, M.CieplakThe volume of cavities in proteins and virus capsids.Proteins 84, 1275-1286 (2016)

• M.Kowiel, D.Brzezinski, M.JaskolskiConformation-dependent restraints for polynucleotides: I. clustering of the geometry of the phosphodiester group.Nucleic Acids Res. 44, 8479-8489 (2016)

• B.Rupp, A.Wlodawer, W.Minor, J.R.Helliwell, M.JaskolskiCorrecting the record of structural publications requires joint effort of the community and journal editors.FEBS J. 283, 4452-4457 (2016)

• P.Drozdzal, M.Gilski, M.JaskolskiUltrahigh-resolution centrosymmetric crystal structure of Z-DNA reveals the massive presence of alternate conformations.Acta Cryst. D72, 1203-1211 (2016)

• J.Raczynska, A.Wlodawer, M.JaskolskiPrior knowledge or freedom of interpretation? A critical look at a recently published classification of “novel” Zn binding sites.Proteins 84, 770-776 (2016)

• W.Minor, Z.Dauter, J.R.Helliwell, M.Jaskolski, A.WlodawerSafeguarding structural data repositories against bad apples.Structure 24, 216-220 (2016)

• J.Sliwiak, R.Dolot, K.Michalska, K.Szpotkowski, G.Bujacz, M.Sikorski, M.Jaskolski Crystallographic and CD probing of ligand-induced conformational changes in a plant PR-10 protein.J. Struct. Biol. 193, 55-66 (2016)

• J.Sliwiak, Z.Dauter, M.Kowiel, A.McCoy, R.J.Read, M.JaskolskiANS complex of St John’s wort PR-10 protein with 28 copies in the asymmetric unit: a fiendish combination of pseudosymmetry with tetartohedral twinning.Acta Cryst. D71, 829-843 (2015)

• A.Wlodawer, Z.Dauter, W.Minor, R.Stanfield, P.Porebski, M.Jaskolski, E.Pozharski, C.X.Weichenberger, B.Rupp (2018) Detect, Correct, Retract: How to manage incorrect structural models. FEBS J. 285, 444-466.

• J.Raczynska, I.Shabalin, W.Minor, A.Wlodawer, M.Jaskolski (2018) A close look onto structural models and primary ligands of metallo-beta-lactamases. Drug Resistance Updates 40, 1-12.

• J.Sliwiak, M.Sikorski, M.Jaskolski (2018) PR-10 proteins as potential mediators of melatonin-cytokinin cross-talk in plants: crystallographic studies of LlPR-10.2B isoform from yellow lupine. FEBS J. 285, 1907-1922.

• K.Eichstaedt, K.Szpotkowski, M.Grajda, M.Gilski, S.Wosicki, M.Jaskolski, A.Szumna (2018) Self-assembly and ordering of peptide-based cavitands in water and DMSO – the power of hydrophobic effects combined with neutral hydrogen bonds. Chem. Eur. J. 25, 3091-3097.

• M.Kowiel, D.Brzezinski, P.Porebski, I.G.Shabalin, M.Jaskolski, W.Minor (2019) Automatic recognition of ligands in electron density by machine learning. Bioinformatics 35, 452-461.

• R.Saini, M.Jaskolski, S.J.Davis (2019) Circadian oscillator proteins across the kingdoms of life: structural aspects. BMC Biology 17:13.M.Gilski, J.Zhao, M.Kowiel, D.Brzezinski, D.H.Turner, M.Jaskolski (2019) Accurate geometrical restraints for Watson-Crick base pairs. Acta Cryst. B75, 235-245.

• Structure-guided design of inhibitors of metallo--lactamases. NCRD – JPI AMR international programs

• Suppramolecular peptide organic assemblies as frameworks for protein crystallization. NSC – SYMFONIA 4

• 3D domain swapping,
• amyloidogenic proteins,
• hydrolytic enzymes,
• protease inhibitors,
• antileukemic asparaginases,
• isoaspartyl amino­peptidases,
• Ntn-hydrolases,
• retroviral protease,
• metallo--lactamases,
• plant pathogenesis-related proteins,
• phytohormone binding proteins,
• plant-bacterium symbiosis,
• crystal structure of nucleic acids,
• atomic-resolution biocrystallography,
• crystallographic methodology,
• supramolecular crystallography

Development of crystallographic methodology and crystallographic studies of the structure of proteins and nucleic acids:

• aggregation mechanisms of amyloidogenic proteins

• hydrolase-inhibitor systems in health and disease

• metallo--lactamases

• phytohormone binding proteins

• plant-bacterium symbiosis

• structural biology of nucleic acids

• macromolecular structure at ultimate resolution

• crystallography of supramolecular systems