Department of Crystallography - Center for Biocrystallographic Research

Prof. Mariusz Jaskólski

Head of Department
mariuszj@ibch.poznan.pl
ext. 1245

Wojciech Witek MSc

PhD student

Stanisław Wosicki MSc

PhD student

PhD students:

Ha Linh Tran
 doktorant

Dr. habil. Mirosław Gilski

starszy specjalista chemik

Dr. Barbara Imiołczyk

starszy specjalista biolog

Technical Staff:

Dr. habil. Dariusz Brzeziński

adiunkt

Dr. Miłosz Ruszkowski

adiunkt

Dr. Kamil Szpotkowski

adiunkt

Dr. Paweł Drożdżal

adiunkt

Researchers:

  • A.Wlodawer, Z.Dauter, W.Minor, R.Stanfield, P.Porebski, M.Jaskolski, E.Pozharski, C.X.Weichenberger, B.RuppDetect, Correct, Retract: How to manage incorrect structural models.FEBS J. 1-10 (2017)

  • M.Chwastyk, M.Jaskolski, M.CieplakThe volume of cavities in proteins and virus capsids.Proteins 84, 1275-1286 (2016)

  • M.Kowiel, D.Brzezinski, M.JaskolskiConformation-dependent restraints for polynucleotides: I. clustering of the geometry of the phosphodiester group.Nucleic Acids Res. 44, 8479-8489 (2016)

  • B.Rupp, A.Wlodawer, W.Minor, J.R.Helliwell, M.JaskolskiCorrecting the record of structural publications requires joint effort of the community and journal editors.FEBS J. 283, 4452-4457 (2016)

  • P.Drozdzal, M.Gilski, M.JaskolskiUltrahigh-resolution centrosymmetric crystal structure of Z-DNA reveals the massive presence of alternate conformations.Acta Cryst. D72, 1203-1211 (2016)

  • J.Raczynska, A.Wlodawer, M.JaskolskiPrior knowledge or freedom of interpretation? A critical look at a recently published classification of “novel” Zn binding sites.Proteins 84, 770-776 (2016)

  • W.Minor, Z.Dauter, J.R.Helliwell, M.Jaskolski, A.WlodawerSafeguarding structural data repositories against bad apples.Structure 24, 216-220 (2016)

  • J.Sliwiak, R.Dolot, K.Michalska, K.Szpotkowski, G.Bujacz, M.Sikorski, M.Jaskolski Crystallographic and CD probing of ligand-induced conformational changes in a plant PR-10 protein.J. Struct. Biol. 193, 55-66 (2016)

  • J.Sliwiak, Z.Dauter, M.Kowiel, A.McCoy, R.J.Read, M.JaskolskiANS complex of St John’s wort PR-10 protein with 28 copies in the asymmetric unit: a fiendish combination of pseudosymmetry with tetartohedral twinning.Acta Cryst. D71, 829-843 (2015)

  • A.Wlodawer, Z.Dauter, W.Minor, R.Stanfield, P.Porebski, M.Jaskolski, E.Pozharski, C.X.Weichenberger, B.Rupp (2018) Detect, Correct, Retract: How to manage incorrect structural models. FEBS J. 285, 444-466.

  • J.Raczynska, I.Shabalin, W.Minor, A.Wlodawer, M.Jaskolski (2018) A close look onto structural models and primary ligands of metallo-beta-lactamases. Drug Resistance Updates 40, 1-12.

  • J.Sliwiak, M.Sikorski, M.Jaskolski (2018) PR-10 proteins as potential mediators of melatonin-cytokinin cross-talk in plants: crystallographic studies of LlPR-10.2B isoform from yellow lupine. FEBS J. 285, 1907-1922.

  • K.Eichstaedt, K.Szpotkowski, M.Grajda, M.Gilski, S.Wosicki, M.Jaskolski, A.Szumna (2018) Self-assembly and ordering of peptide-based cavitands in water and DMSO – the power of hydrophobic effects combined with neutral hydrogen bonds. Chem. Eur. J. 25, 3091-3097.

  • M.Kowiel, D.Brzezinski, P.Porebski, I.G.Shabalin, M.Jaskolski, W.Minor (2019) Automatic recognition of ligands in electron density by machine learning. Bioinformatics 35, 452-461.

  • R.Saini, M.Jaskolski, S.J.Davis (2019) Circadian oscillator proteins across the kingdoms of life: structural aspects. BMC Biology 17:13.M.Gilski, J.Zhao, M.Kowiel, D.Brzezinski, D.H.Turner, M.Jaskolski (2019) Accurate geometrical restraints for Watson-Crick base pairs. Acta Cryst. B75, 235-245.

Selected publications

  • Structure-guided design of inhibitors of metallo--lactamases. NCRD – JPI AMR international programs

  • Suppramolecular peptide organic assemblies as frameworks for protein crystallization. NSC – SYMFONIA 4

Research activity

  • 3D domain swapping,
  • amyloidogenic proteins,
  • hydrolytic enzymes,
  • protease inhibitors,
  • antileukemic asparaginases,
  • isoaspartyl amino­peptidases,
  • Ntn-hydrolases,
  • retroviral protease,
  • metallo--lactamases,
  • plant pathogenesis-related proteins,
  • phytohormone binding proteins,
  • plant-bacterium symbiosis,
  • crystal structure of nucleic acids,
  • atomic-resolution biocrystallography,
  • crystallographic methodology,
  • supramolecular crystallography

Development of crystallographic methodology and crystallographic studies of the structure of proteins and nucleic acids:

  • aggregation mechanisms of amyloidogenic proteins

  • hydrolase-inhibitor systems in health and disease

  • metallo--lactamases

  • phytohormone binding proteins

  • plant-bacterium symbiosis

  • structural biology of nucleic acids

  • macromolecular structure at ultimate resolution

  • crystallography of supramolecular systems

 

Research area

Keywords

Research Projects

Media Społecznościowe

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Cooperation

Institute of Bioorganic Chemistry,
Polish Academy of Sciences
Z. Noskowskiego 12/14
61-704 Poznań
tel centrala: (+48) 61 852 85 03
fax: (+48) 61 852 05 32
e-mail: ibch@ibch.poznan.pl

Sekretariat Dyrektora, tel: 61 852 89 19

Adress