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Institute of Bioorganic Chemistry,
Polish Academy of Sciences
Z. Noskowskiego 12/14
61-704 Poznań
tel centrala: (+48) 61 852 85 03
fax: (+48) 61 852 05 32

Sekretariat Dyrektora, tel: 61 852 89 19


Department of Molecular Neurooncology

Dr. habil. Katarzyna Rolle

Head of Department
618291860 office, 618291866 lab

Konrad Kuczyński MSc

PhD student

Adriana Grabowska MSc

PhD student

Małgorzata Grabowska MSc

PhD student

Żaneta Zarębska MSc

PhD student

PhD students:

Paweł Głodowicz MSc Eng


Julia Latowska MSc


Technical Staff:

Dr. Julia Misiorek


  • Misiorek JO, Przybyszewska-Podstawka A, Kałafut J, Paziewska B, Rolle K, Rivero-Muller A, Nees M. Context Matters: NOTCH Signatures and Pathway in Cancer Progression and Metastasis, Cells, 10(1): 94 (2021)

  • Misiorek JO, Schreiber AM, Urbanek-Trzeciak MO, Jazurek-Ciesiołka M, Hauser LA, Lynch DR, Napierala JS, Napierala M. A comprehensive transcriptome analysis identifies FXN and BDNF as novel targets of miRNAs in Friedreich’s ataxia patients. Mol Neurobiol., 57(6): 2639–2653 (2020)

  • Wawrzyniak D, Grabowska M, Głodowicz P, Kuczyński K, Kuczyńska B, Fedoruk-Wyszomirska A, Rolle K. Down-regulation of tenascin-C inhibits breast cancer cells development by cell growth, migration, and adhesion impairment. PLoS ONE 15(8):e0237889 (2020)

  • Wawrzyniak O, Zarębska Ż, Kuczyński K, Gotz-Więckowska A, Rolle K. Protein-Related Circular RNAs in Human Pathologies. Cells  6;9(8):E1841 (2020)

  • Grabowska M, Grześkowiak BF, Szutkowski K, Wawrzyniak D, Głodowicz P, Barciszewski J, Jurga S, Rolle K, Mrówczyński R. Nano-mediated delivery of double-stranded RNA for gene therapy of glioblastoma multiforme. PLOS One 14(3) 2793 (2019)

  • Szymańska-Michalak A, Wawrzyniak D, Framski G, Stawiński J, Barciszewski J, Kraszewski A. New antiglioma zwitterionic pronucleotides with a FdUMP framework. Eur. J. Med. Chem. 144:682-691 (2018)

  • Belter A, Rolle K, Piwecka M, Fedoruk-Wyszomirska A, Naskręt-Barciszewska MZ, Barciszewski J. Inhibition of miR-21 in glioma cells using catalytic nucleic acids. Sci. Rep. 15; 6:24516 (2016)

  • Rolle K, Piwecka M, Belter A, Wawrzyniak D, Jeleniewicz J, Barciszewska MZ, Barciszewski J. The sequence and structure determine the function of mature human miRNAs. PLOS One 11(3), e0151246 (2016)

  • Sultan LD, Mileshina D, Grewe F, Rolle K, Abudraham S, Głodowicz P, Niazi AK, Keren I, Shevtsov S, Klipcan L, Barciszewski J, Mower JP, Dietrich A, Ostersetzer-Biran O. The Reverse Transcriptase/RNA Maturase Protein MatR Is Required for the Splicing of Various Group II Introns in Brassicaceae Mitochondria. Plant Cell 28:2805-2829 (2016)

  • Framski G, Wawrzyniak D, Jahnz-Wechmann Z, Szymańska-Michalak A, Kraszewski A, Barciszewski J, Boryski J, Stawiński J. Searching for anti-glioma activity. Ribonucleoside analogues with modifications in nucleobase and sugar moieties. Acta Biochim. Pol. 63:765-77 (2016)

  • Szymańska-Michalak A, Wawrzyniak D, Framski G, Kujda M, Zgoła P, Stawiński J, Barciszewski J, Boryski J, Kraszewski A. New 3′-O-aromatic acyl-5-fluoro-2′-deoxyuridine derivatives as potential anticancer agents. Eur. J. Med. Chem. 115:41-52 (2016)

  • Piwecka M, Rolle K, Belter A, Barciszewska AM, Żywicki M, Michalak M, Nowak S, Naskręt-Barciszewska MZ, Barciszewski J. Comprehensive analysis of microRNA expression profile in malignant glioma tissues. Mol Oncol. 9:1324-40 (2015)

  • Rolle K. miRNA multiplayers in glioma. From bench to bedside. Acta Biochim Pol. 62: 353-365 (2015)

Selected publications

  • Functional crosstalk between circRNAs and extracellular matrix (ECM) - the importance for glioblastoma stem cells (GSC) and epithelial-mesenchymal transition (EMT) in brain tumors. NSC – OPUS 13 

  •  The characteristics of the regulatory RNAs landscape in glioblastoma multiforme (GBM). Circular RNAs and micro RNA-like molecules as a new players in gilomagenesis and GBM progression and their importance for glioblastoma stem cells (2018-2022). NSC – SONATA BIS 7 

  • Catalytic RNAs as a tool for human mitochondrial biotechnology. NCN – PRELUDIUM 11 

  •  New, multifunctional nanoparticles for combined photothermal and gene silencing cancer therapy. NCN – OPUS 11 

Research activity

  • brain tumors,
  • glioblastoma multiforme,
  • cancer development and progression,
  • cancer stem cells,
  • regulatory RNAs,
  • circular RNAs, miRNAs,
  • extracellular matrix,
  • epithelial-mesenchymal transition

The main goal of the Department of Molecular Neurooncology is the complex research of the basics of development and progression of brain tumors, especially glioblastoma multiforme (GBM). Our interests include mainly:

  • the identification and characteristics of the regulatory RNAs crucial for the cancer development, such as  miRNA, lncRNA and circRNA, especially their importance for cancer stem cells and processes like: unlimited cell divisions, ability to form secondary tumors, or eventually resistance to chemotherapy,

  • the establishing the role of extracellular matrix (ECM) components in metastases, resistance to treatment and processes associated with epithelial-mesenchymal transition,

  • the identification of RNA molecules with potential diagnostic, prognostic and therapeutic significance.

In our experimental approach we use a combination of molecular biology tools, in vivo imaging techniques with functional studies using clinical tissue samples, human cell lines (including primary tumor cells isolated from patients) and syngeneic mouse tumor models.


Research area


Research Projects

Prof. Jan Barciszewski

Affiliated professors :

Dr. Dariusz Wawrzyniak