Department of structure and function of biomolecules

Prof. Wojciech Rypniewski

Head of Department
wojtekr@ibch.poznan.pl
ext.
1114

Martyna Pluta MSc

PhD student

Marcin Ryczek MSc. BEng.

PhD student

PhD students:

Katarzyna Biniek-Antosiak MSc

biologist

Technical Staff:

Dr. habil. Agnieszka Kiliszek

profesor

Dr. Leszek Błaszczyk
adiunkt

Dr. Magdalena Bejger
adiunkt

Researchers:

  • S. Mukherjee, L. Blaszczyk, W. Rypniewski, Ch. Falschlunger, R. Micura, A. Murata, Ch. Dohno, K. Nakatani & A. Kiliszek, Structural insights into synthetic ligands targeting A-A pairs in disease-related CAG RNA repeats. Nucleic Acids Res. 47:10906-10913 (2019)

  • A. Kiliszek, W. Rypniewski, K. Rzad, S. Milewski & I. Gabriel, Crystal structures of aminotransferases Aro8 and Aro9 from Candida albicans and structural insights into their properties. J. Struct. Biol. 205:26-33 (2019)

  • A. Kiliszek, L. Blaszczyk, R. Kierzek & W. Rypniewski, Stabilization of RNA hairpins using non-nucleotide linkers and circularization.Nucleic Acids Res. 45:e92 (2017)L. Blaszczyk, W. Rypniewski & A. KiliszekStructures of RNA repeats associated with neurological diseases. WIREs RNA, 8:e1412 (2017)

  • L. Blaszczyk, W. Rypniewski & A. Kiliszek, Structures of RNA repeats associated with neurological diseases.WIREs RNA, 8:e1412 (2017)

  • P.H. Malecki, M. Bejger, W. Rypniewski & C.E. Vorgias, The crystal structure of a Streptomyces thermoviolaceus thermophilic chitinase known for its refolding efficiency. Int. J. Mol. Sci. 21:2892 (2020)

Selected publications

  • How RNA structure governs messenger RNA function? Exploring structural and functional aspects essential for synthesis of p53 protein - a master regulator of vital cellular functions. NSC – SONATA 12

Research activity

  • structure and function of biomolecules,

  • biological crystallography,

  • protein structure,

  • RNA structure,

  • chitinase,

  • chitosanase,

  • chitin deacetylase,

  • extremophile,

  • thermophile,

  • psychrophile,

  • tri-nucleotide RNA repeats,

  • RNA hairpins, TREDs,

  • neurodegenerative diseases

The three-dimensional structure of biomolecules determines their properties and function, and X-ray crystallography is a leading technique for investigating molecular structures in atomic detail. Our department uses crystallography to determine the relationship between the structure and function of proteins and nucleic acids. The main areas of our interest are:

  • pathogenic RNA sequences that cause neurodegenerative disorders known as TREDs, and interactions of such sequences with potential therapeutics

  • chitinolythic enzymes, especially from extremophiles, as a material for constructing an artificial chitinosome

  • proteins from extremophiles as models for investigating the bases of adaptation of organisms to extreme environmental conditions, in particular to identify those elements of the structure that are responsible for proteins’ stability in thermophiles and enzymatic efficiency in psychrophiles.

  • proteins from pathogens as therapeutic targets, eg. thymidylate synthase, aminotransferases, urease

  • proteins and their enzymatic reaction mechanisms at ultra-high resolution.

 

Research Projects

Keywords

Research Projects

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Cooperation

Institute of Bioorganic Chemistry,
Polish Academy of Sciences
Z. Noskowskiego 12/14
61-704 Poznań
tel centrala: (+48) 61 852 85 03
fax: (+48) 61 852 05 32
e-mail: ibch@ibch.poznan.pl

Sekretariat Dyrektora, tel: 61 852 89 19

Adress