Department of Structure and Function of Retrotransposons

Dr. habil. Katarzyna Pachulska-Wieczorek

Head of Department
kasiapw@ibch.poznan.pl
ext.
1193

Angelika Andrzejewska MSc. BEng.
 
PhD student

Małgorzata Zawadzka MSc
PhD student

PhD students:

Julita Gumna MSc 
biologist

Technical Staff:

Dr. Katarzyna Purzycka
adiunkt

Researchers:

Prof. Ryszard W. Adamiak

profesor

Affiliated professors :

  • Lepeta K, Purzycka KJ, Pachulska-Wieczorek K, Mitjans M, Begemann M, Vafadari B, Bijata K, Adamiak RW, Ehrenreich H, Dziembowska M, Kaczmarek LA normal genetic variation modulates synaptic MMP-9 protein levels and the severity of schizophrenia symptoms.EMBO Molecular Medicine, 9(8):1100-1116 (2017)

  • Z. Miao, R.W. Adamiak, M. Antczak, R.T. Batey, A.J. Becka, M. Biesiada, M.J. Boniecki, J. Bujnicki, S.J. Chen, C.Y. Cheng, F.C. Chou, A.R. Ferré-D’Amaré, R. Das, W.K. Dawson, D. Feng, N.V. Dokholyan, S. Dunin-Horkawicz, C. Geniesse, K. Kappel, W. Kladwang, A. Krokhotin, G.E. Łach, F. Major, T.H. Mann, M. Magnus, K. Pachulska-Wieczorek, D.J. Patel, J.A. Piccirilli, M. Popenda, K.J. Purzycka, A. Ren, G.M. Rice, J.J. Santalucia, J. Sarzynska, M. Szachniuk, M. Tandon, J.J. Trausch, S.Tian, J. Wang, K.M. Weeks, B. Williams, Y. Xiao, X. Xu, D. Zhang, T. Zok, E. WesthofRNA-Puzzles Round III: 3D RNA structure prediction of five riboswitches and one ribozyme.RNA, 23(5):655-672 (2017)

  • Gómez Ramos LM, Degtyareva NN, Kovacs NA, Holguin SY, Jiang L, Petrov AS, Biesiada M, Hu MY, Purzycka KJ, Arya DP, Williams LD.Eukaryotic Ribosomal Expansion Segments as Antimicrobial Targets.Biochemistry, 56(40):5288-5299 (2017)

  • Błaszczyk L, Biesiada M, Saha A, Garfinkel DJ, Purzycka KJ.Structure of Ty1 Internally Initiated RNA Influences Restriction Factor Expression.Viruses, 9(4). pii: E74 (2017)

  • K. Pachulska-Wieczorek, S.F. Le Grice, K.J. PurzyckaDeterminants of Genomic RNA Encapsidation in the Saccharomyces cerevisiae Long Terminal Repeat Retrotransposons Ty1 and Ty3.Viruses, 8(7) (2016)

  • M. Biesiada, K. Pachulska-Wieczorek, R.W. Adamiak, K.J. PurzyckaRNAComposer and RNA 3D structure prediction for nanotechnology.Methods, 103:120-7 (2016)

  • D.J. Garfinkel, J.M. Tucker, A. Saha, Y. Nishida, K. Pachulska-Wieczorek, L. Błaszczyk, K.J. PurzyckaA self-encoded capsid derivative restricts Ty1 retrotransposition in Saccharomyces.Curr Genet., 62(2):321-9 (2016)

  • K. Pachulska-Wieczorek, L. Błaszczyk, M. Biesiada, R.W. Adamiak, K.J. PurzyckaThe matrix domain contributes to the nucleic acid chaperone activity of HIV-2 Gag.Retrovirology, 13:18 (2016)

  • K. Pachulska-Wieczorek, L. Błaszczyk, J. Gumna, Y. Nishida, A. Saha, M. Biesiada, D.J. Garfinkel, K.J. PurzyckaCharacterizing the functions of Ty1 Gag and the Gag-derived restriction factor p22/p18.Mob Genet Elements, 6(2):e1154637 (2016)

  • Biesiada M, Purzycka KJ, Szachniuk M, Blazewicz J, Adamiak RW,Automated RNA 3D Structure Prediction with RNAComposer.Methods Mol Biol.;1490:199-215 (2016)

  • Y. Nishida, K. Pachulska-Wieczorek, L. Błaszczyk, A. Saha, J. Gumna, D.J. Garfinkel, K.J. PurzyckaTy1 retrovirus-like element Gag contains overlapping restriction factor and nucleic acid chaperone functions.Nucleic Acids Res., 3;43(15):7414-31 (2015)

Selected publications

  • RNA structures and interactions with Gag protein that specify Ty1 RNA functions during retrotransposon replication. NSC – SONATA BIS 6

Research activity

  • retrotransposons,
  • retroviruses,
  • RNA structure,
  • nucleic acid chaperone proteins,
  • Gag, Ty1,
  • HIV,
  • HERV
  • RNA structure and transitions on both 2D and 3D structure levels that specify RNA function at different stages of retroelements’ replication.

  • Functions of Gag and Gag-derived proteins.

  • Nucleic acid chaperone activity of proteins.

  • Evolution of RNA structure.

Research area

Keywords

Research activity

Media Społecznościowe

Strona zrobiona w kreatorze stron internetowych WebWave

Cooperation

Institute of Bioorganic Chemistry,
Polish Academy of Sciences
Z. Noskowskiego 12/14
61-704 Poznań
tel centrala: (+48) 61 852 85 03
fax: (+48) 61 852 05 32
e-mail: ibch@ibch.poznan.pl

Sekretariat Dyrektora, tel: 61 852 89 19

Adress