Laboratory of Animal Model Organisms

Dr. habil. Agata Tyczewska, associate professor

Head of Laboratory

agatat@ibch.poznan.pl
ext. 1134

Research Projects

Keywords

Caenorhabditis elegans,
C. elegans,
aging,
tRNA-derived fragments (tRF),
microinjection,
MediaJet,
Mediaclave,
Tissue Lyser,
GMO,
PC-100 micro needle puller,
nutrient media Integra,
biotechnology,
bioeconomy,
GMO legislation,
public perception of GMO,
intellectual property rights (IPR)

Offer

Nutrient media sterilization (from 1 l to 10 l)
Petri plates pouring, up to 900 plates per hour (Ø 35 mm, 60 mm, 90 mm)
Microneedle preparation
Microinjections (possibility to use with C. elegans, cell nuclei and cytomplasm of adherent cells, pronucleuses of fertilized mouse oocytes, Xenopus laevis oocytes, fish embryos in early development phases)

Equipment

Mediaclave 10, Integra
MediaJet vario, with sets for Ø 35 mm, 60 mm, 90 mm Petri plates, Integra
PC-100 microneedle puller, Narishige
Axio Vert.A1 microscope (Zeiss), with the Eppendorf microinjection set mounted:
the InjectMan ®4 micromanipulator with dynamic motion control and the programmable FemtoJet ®4i micro diaphragm with integrated pressure supply
Tissue Lyser with 2 x 24 Adapter Set for 2 ml tubes, and Grinding Jar Set (stainless steel, 2 x 10 ml)

Research activity

Low-molecular weight drug screening using C. elegans.
Identification and characterization of tRNA-derived fragments (tRFs) during aging in Caenorhabditis elegans.
Social and legal aspects of biotechnology: intellectual property, legislation, social perception
Analysis of the condition of Polish, European and global biotechnology and bioeconomy

Selected publications

Tyczewska A, Rzepczak A, Sobańska D, Grzywacz (2023) The emerging roles of tRNAs and tRNA-derived fragments during aging: Lessons from studies on model organisms. Ageing Research Reviews; 101863; https://doi.org/10.1016/j.arr.2023.101863
Aygün I, Rzepczak A, Miki TS (2023) A germline-targeted genetic screen for xrn-2 suppressors identifies a novel gene C34C12.2 in Caenorhabditis elegans. Genet Mol Biol. 46(2): e20220328. https://doi.org/10.1590/1678-4685-GMB-2022-0328
Tyczewska A, Twardowski T, Woźniak-Gientka E (2023) Agricultural biotechnology for sustainable food security. Trends in Biotechnology 41(3): 331-334; https://doi.org/10.1016/j.tibtech.2022.12.013
A. Tyczewska, K. Grzywacz (2022) tRNA-derived fragments as new players in regulatory processes in yeast. Yeast, https://doi.org/10.1002/yea.3829
Sobanska D, Komur AA, Chabowska-Kita A, Gumna J, Kumari P, Pachulska-Wieczorek K, Ciosk R (2022) The silencing of ets-4 mRNA relies on the functional cooperation between REGE-1/Regnase-1 and RLE-1/Roquin-1. Nucleic Acids Research 50: 8226-8239; https://doi.org/10.1093/nar/gkac609
Pekec T, Lewandowski J, Komur AA, Sobanska D, Guo Y, Switonska-Kurkowska K, Malecki JM, Dubey AA, Pokrzywa W, Frankowski M, Figiel M, Ciosk R (2022) Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons. Nature Communications 13:4883; https://doi.org/10.1038/s41467-022-32500-z
Woźniak-Gientka E, Tyczewska A, Perisic M, Beniermann A, Eriksson D, Vangheluwe N, Gheysen G, Cetiner S, Abiri N, Twardowski T (2022) Public perception of plant gene technologies worldwide in the light of food security. GM Crops & Food 13(1), 218-241, https://doi.org/10.1080/21645698.2022.2111946
Woźniak E, Tyczewska A, Twardowski T (2021) Bioeconomy development factors in the European Union and Poland. New Biotechnology, 60:2-8, doi: 10.1016/j.nbt.2020.07.004
Woźniak E, Tyczewska A, Twardowski T (2021) A shift towards biotechnology: Social opinion in the EU. Trends in Biotechnology 39(3), 214–218, doi: 10.1016/j.tibtech.2020.08.001
Zimny T, Sowa S, Tyczewska A, Twardowski T (2019) Certain new plant breeding techniques and their marketability in the context of EU GMO legislation – recent developments. New Biotechnology 51, 49-56, doi: 10.1016/j.nbt.2019.02.003
Tyczewska A, Woźniak E, Gracz J, Kuczyński J, Twardowski T (2018) Towards Food Security: Current State and Future Prospects of Agrobiotechnology. Trends in Biotechnology, 36(12):1219-1229, doi: 10.1016/j.tibtech.2018.07.008
Gracz J, Tyczewska A, Twardowski T (2015) Perspectives and challenges of plants breeding in the post-genomic era (in Polish). Nauka 2, 109-126
Tyczewska A (2014) Patents – an important added value for economy and science. BioTechnologia. Journal of Biotechnology, Computational Biology and Bionanotechnology 95(4), 243-250, doi: https://doi.org/10.5114/bta.2014.56592

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Laboratory of Animal Model Organisms

Researchers:

Technical Staff:

PhD students:

Research Projects

Keywords

Offer

Equipment

Research activity

Selected publications

Adres

Address

Laboratory of Animal Model Organisms

Researchers:

Technical Staff:

PhD students:

Research Projects

Keywords

Sample Title

Sample Title

Offer

Equipment

Research activity

Selected publications

Adres

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