Department of Biopolymers Chemistry

dr hab. Marcin K. Chmielewski

Dr. hab. Marcin K. Chmielewski​, prof. IBCH PAS

Head of Department

chmielewskimk@ibch.poznan.pl
ext.​ ​1257

Researchers:

Stanisław Trzciński PhD
Assistant Professor

dr Justyna Gołębiewska
główny specjalista ds. środowiskowej aparatury badawczej

Research activity

Research area
  • Chemical synthesis of biopolymers with particular emphasis on nucleic acids, peptides, carbohydrates, lipids and their modifications.
  • Research on new, functional polymeric materials with application potential, e.g. as drug carriers or supports in chemical solid-phase synthesis.
  • Application of the original thermocyclization reaction in a broad aspect of chemical synthesis.
  • Thermosensitive technology as a tool in the design of protection groups, a new class of fluorescent tracers, catalysts with thermodependent activity, thermo-release polymers and molecular thermometers.
  • Qualitative and quantitative instrumental analysis using PVA capillary electrophoresis, high-performance HPLC column chromatography with UV-Vis, fluorescence and Corona detectors, and MALDI-TOF-MS mass analysis.
  • Synthesis of novel functional biomaterials such as modified biocompatible chitin.
  • Synthesis of new complex compounds of thermolabile group precursors with d-electron metals.
  • Understanding the chemical nature of the studied compounds, determining the mechanism of the processes taking place and obtaining new useful materials for use in the broadly understood field of life sciences.
Keywords
  • biopolymers,
  • chemical synthesis of nucleic acids,
  • thermolabile protection groups,
  • TGO,
  • TPG,
  • thermolabile fluorescent tags,
  • DNA,
  • RNA,
  • oligonucleotides,
  • SPOS,
  • LPOS,
  • solid supports,
  • CPG,
  • liquid supports,
  • modifications
  • triphosphates,
  • chitin,
  • thermolability,
  • cross-linking,
  • polymers,
  • RAFT,
  • biomaterials,
  • peptides,
  • PNA,
  • fluorescent dyes,
  • fluorescence,
  • FRET,
  • aptamers,
  • aminoalcohols,
  • d-block metal complexes,
  • thermosensitive catalysts,
  • functional groups,
  • nanostructures,
  • nanodevices,
  • nanomachines,
  • markers,
  • large-scale synthesis,
  • HPLC,
  • capillary electrophoresis,
  • PVA,
  • MALDI.

Research projects

  • Development of universal fast-response platform based on RNA technology, ensuring the national drug and epidemiological safety (ABM Project Call: Development of innovative therapeutic solutions with RNA technology; project carried out in consortium with Polfa SA; principal investigator of Task No. 2: M.K. Chmielewski)
  • Development of large-scale synthesis of nucleic acids using hybrid substrates (National Centre for Research and Development, Smart Growth Operational Programme 2014-2020 Fast Track, project implemented in a consortium, project leader: FutureSynthesis sp. z o.o., task manager on behalf of IBCH PAS: M.K. Chmielewski)
  • Implementation of the method of producing 5'triphorylated nucleic acids (NCBiR, TANGO, head of the project: M.K. Chmielewski)
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