Department of Molecular Genetics

Department Of Molecular Genetics

Prof. Piotr Kozłowski

Head of Department

kozlowp@ibch.poznan.pl
ext. 1261

Research activity

Research area

Cancer genetics
Methodology of CNV polymorphism analysis
Polymorphism and somatic variation of miRNA genes
The role of circRNA in myotonic dystrophy type 1 (DM1)

Keywords

Cancer genetics
Copy number variation polymorphism (CNV)
Multiplex ligation-depent probe amplification (MLPA)
miRNA
lncRNA
circRNA

Research Projects

The effect of cancer somatic mutations in miRNA genes on the functioning of these genes and their potential role in cancer. NSC SONATA16, 2020/39/D/NZ2/03106, PI: Paulina Galka-Marciniak, PhD.
Identification of cancer-driver mutations in non-coding parts of protein-coding genes and long non-coding RNA genes. NSC OPUS20, 2020/39/B/NZ5/01970, PI: Piotr Kozlowski, Prof.
Cancer Genetics: Identification and Analysis of Oncogenic Somatic Mutations in miRNA. Fulbright U.S. Student Researcher 2020/2021. PI: Piotr Kozlowski, Prof.
Antibiotic resistance genes and integrons as indicators of biotic pollution and the resistance burden of Arctic ecosystems. NSC SONATINA4, 2020/36/C/NZ9/00221, PI: Nicoletta Makowska-Zawierucha, PhD.
Analysis of somatic mutations in miRNA and miRNA-biogenesis genes to identify new therapeutic targets and biomarkers of cancer. NSC MAESTRO 8, 2016/22/A/NZ2/00184 , PI: Piotr Kozlowski, Prof.
Analysis of BARD1 gene in genetic predisposition to breast cancer- utilization of unique strategy of association of founder mutations. NSC OPUS9, 2015/17/B/NZ2/01182, PI: Piotr Kozlowski, Prof.
Expression of circular RNAs in myotonic dystrophy type 1- implication to pathogenesis. NSC PRELUDIUM 11, 2016/21/N/NZ5/00508, PI: Karol Czubak, PhD.
The APOBEC3B deletion- analysis of its role in familial breast cancer predisposition of its consequences on mRNA level. NCN PRELUDIUM10, 2015/19/N/NZ5/02247, PI: Katarzyna Klonowska, PhD.
Elucidation of the molecular causes and effects of elevated circular RNAs expression levels in myotonic dystrophy type 1 (DM1). NCN OPUS7, 2014/13/B/NZ5/03214, PI: Marzena Wojciechowska, Prof.

Selected publications

Suszynska M, Machowska M, Fraszczyk E, Michalczyk M, Philips A, Galka-Marciniak P, Kozlowski P. CMC: Cancer miRNA Census – a list of cancer-related miRNA genes. Nucleic Acids Res. 2024 Jan 23:gkae017. doi: 10.1093/nar/gkae017
Szóstak N, Handschuh L, Samelak-Czajka A, Tomela K, Schmidt M, Pruss Ł, Milanowska-Zabel K, Kozlowski P, Philips A. Host factors associated with gut mycobiome structure. mSystems. 2023 Apr27;8(2):e0098622. doi: 10.1128/msystems.00986-22.
Lewandowski K, Kopydłowska A, Kanduła Z, Sankowski B, Machnicki M, Barańska M, Gwóźdź-Bąk K, Kubicki T, Plotka A, Przysiecka Ł, Dworacki G, Kozłowski P, Stokłosa T. HRAS mutation positive multiple myeloma in the type 2 CALR mutation positive essential thrombocythemia: A case report. J Cell Mol Med. 2023 Jan:27(2):299-303. doi: 10.1111/jcmm.17647.
Suszynska M, Adamiak M, Thapa A, Cymer M, Ratajczak J, Kucia M, Ratajczak MZ. Purinergic Signaling and Its Role in Mobilization of Bone Marrow Stem Cells. Methods Mol Biol. 2023;2567:263-280. doi: 10.1007/978-1-0716-2679-5_17.
Machowska M, Galka-Marciniak P, Kozlowski P. Consequences of genetic variants in miRNA genes. Comput Struct Biotechnol J. 2022 Nov 19;20:6443-6457. doi: 10.1016/j.csbj.2022.11.036.
Lewandowski K, Kanduła Z, Gniot M, Paczkowska E, Nawrocka PM, Wojtaszewska M, Janowski M, Mariak M, Handschuh L, Kozlowski P. Essential thrombocythaemia in progression to the fibrotic phase is associated with the decrease in JAK2 and PDL1 levels. Ann Hematol. 2022 Oct 21. Annals of Hematology 2022.doi:10.1007/s00277-022-05001-8
Galka-Marciniak P, Kandula Z, Tire A, Wegorek W, Gwozdz-Bak K, Handschuh L, Giefing M, Lewandowski K, Kozlowski P. Mutations in the mir-142 gene are not common in myeloproliferative neoplasms. Sci. Rep. 2022, 12: 10924
Urbanek-Trzeciak MO, Kozlowski P, Galka-Marciniak P. miRMut: Annotation of mutations in miRNA genes from human whole-exome or whole-genome sequencing. STAR Protoc. 2022, 3(1):101023
Suszynska M, Ratajska M, Galka-Marciniak P, Ryszkowska A, Wydra D, Debniak J, Jasiak A, Wasag B, Cybulski C, Kozlowski P. Variant Identification in BARD1, PRDM9, RCC1, and RECQL in Patients with Ovarian Cancer by Targeted Next-generation Sequencing of DNA Pools. Cancer Prev Res (Phila). 2022. doi: 10.1158/1940-6207.CAPR-21-0295. Online ahead of print.
Nawrocka PM, Galka-Marciniak P, Urbanek-Trzeciak MO, M-Thirusenthilarasan I, Szostak N, Philips A, Susok L, Sand M, Kozlowski P. Profile of Basal Cell Carcinoma Mutations and Copy Number Alterations - Focus on Gene-Associated Noncoding Variants. Front Oncol. 2021, 11, 752579
Golden E, Rashwan R, Woodward EA, Sgro A, Wang E, Sorolla A, Waryah C, Tie WJ, Cuyas E, Ratajska M, Kardaś I, Kozlowski P, Johnstone EKM, See HB, Duffy C, Parry J, Lagerborg KA, Czapiewski P, Menendez JA, Gorczyński A, Wasag B, Pfleger KDG, Curtis C, Lee BK, Kim J, Cursons J, Pavlos NJ, Biernat W, Jain M, Woo AJ, Redfern A, Blancafort P. The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer. Nat Commun. 2021, 12, 1920
Galka-Marciniak P, Urbanek-Trzeciak MO, Nawrocka PM, Kozlowski P. A pan-cancer atlas of somatic mutations in miRNA biogenesis genes. Nucleic Acids Res. 2021, 49, 601-620
Urbanek-Trzeciak MO, Galka-Marciniak P, Nawrocka PM, Kowal E, Szwec S, Giefing M, Kozlowski P. Pan-cancer analysis of somatic mutations in miRNA genes. EBioMedicine. 2020, 61:103051
Suszynska M, Kozlowski P. Summary of BARD1 Mutations and Precise Estimation of Breast and Ovarian Cancer Risks Associated with the Mutations. Genes (Basel). 2020, 11(7): 798
Suszynska M, Ratajska M, Kozlowski P. BRIP1, RAD51C, and RAD51D mutations are associated with high susceptibility to ovarian cancer: mutation prevalence and precise risk estimates based on a pooled analysis of ~30,000 cases. J Ovarian Res. 2020, 13(1): 50
Czubak K, Sedehizadeh S, Kozlowski P, Wojciechowska M. An Overview of Circular RNAs and Their Implications in Myotonic Dystrophy. Int J Mol Sci. 2019, 20, 4385
Czubak K, Taylor K, Piasecka A, Sobczak K, Kozlowska K, Philips A, Sedehizadeh S, Brook JD, Wojciechowska M, Kozlowski P. Global Increase in Circular RNA Levels in Myotonic Dystrophy. Front Genet. 2019, 18, 649
Galka-Marciniak P, Urbanek-Trzeciak MO, Nawrocka PM, Dutkiewicz A, Giefing M, Lewandowska MA, Kozlowski P. Somatic Mutations in miRNA Genes in Lung Cancer-Potential Functional Consequences of Non-Coding Sequence Variants. Cancers (Basel). 2019, 11, 793

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Department Of Molecular Genetics

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Research activity

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