Department of Structural Biology of Eukaryotes

Dr. habil. Miłosz Ruszkowski

Dr. hab. Miłosz Ruszkowski , prof. IBCH PAS

Head of Department
ext. 1612

Research activity

Research area

Biological macromolecules dictate every aspect of life, but their thorough comprehension is impossible without structural information at the atomic level. Only through structures, it is possible to:
- fully understand catalytic mechanisms of enzymatic reactions;
- reveal interactions of proteins with small molecules, other proteins, DNA, and RNA;
- rationally design bioactive compounds such as drugs or herbicides.
We are particularly interested in plant proteins relevant to modern agriculture and in targets of anticancer therapies. With macromolecular crystallography and cryoelectron microscopy (Cryo-EM), complemented with a broad range of biophysical, biochemical, and bioinformatic methods, we bring new insights into the fascinating world of the molecules of life.

  • biocrystallography,
  • Cryo-EM;
  • drug design;
  • herbicide design;
  • inhibitors;
  • metabolic pathways

Research Projects

  • Design and Development of Serine Hydroxymethyltransferase-2 (SHMT2) Inhibitors Blocking Tumor Growth. NCN Sonata Bis; ; PI dr hab. Milosz Ruszkowski
  • Search for Inhibitors of Human δ1-Pyrroline-5-Carboxylate Reductase 1 (PYCR1) as Lead Molecules for the Development of Novel Anticancer Drugs; NCN Opus; PI dr hab. Milosz Ruszkowski
  • The puzzling structure of Grainyhead-like human transcription factors involved in tumor growth regulation; NCN Sonatina; PI: dr. eng. Maria Rutkiewicz
  • Development of an efficient method of production of WRKY group IIa transcription factors from Arabidopsis thaliana for further structural studies; NCN Miniatura; PI: dr. eng. Marta Grzechowiak
  • Histidine Biosynthetic Pathway in Plants: Structural and Functional Studies as a Framework for the Design of Inhibitors and Activators. NCN SONATA; PI: Dr. hab. Milosz Ruszkowski
  • Novel L-asparaginases as potential therapeutic agents and antimicrobial targets: structural and functional studies of enzymes with dual implications for drug design. NCN OPUS; PI: Prof. Mariusz Jaskolski
  • Validation of PDB models of potential drug design targets for SARS-CoV-2 coronavirus. NCN COVID-19, PI: Prof. Mariusz Jaskolski
  • Functional and Structural Studies of Plant Serine Hydroxymethyltransferases Isoforms and Their Complexes with Small Molecules. PAS-CNR; PI: Dr. hab. Milosz Ruszkowski
  • Supramolecular Peptide Organic Frameworks (POFs). NCN SYMFONIA; Prof. Mariusz Jaskólski (partner).

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