Dr. Monika Piwecka from the IBCH PAS in Poznań, together with scientists from the Max Delbrück Center for Molecular Medicine in Berlin, Dr. Agnieszka Rybak-Wolf and Prof. Nikolaus Rajewsky, has published a review article that summarizes several intensive years of work conducted with single-cell RNA sequencing and spatially-resolved transcriptomics in the context of brain biology. In the review including of more than 200 studies, the authors identified a few areas where these new transcriptomic technologies have had a particular impact, including: understanding of selective neuronal vulnerability, neuroimmune dysfunction and cell-type-specific treatment response. The authors also discuss the limitations and future directions of single-cell RNA sequencing and spatial transcriptomics in the context of neurological disorders. The online press release took place on May 17, 2023.
Piwecka M., Rajewsky N., Rybak-Wolf A. (2023) „Single-cell and spatial transcriptomics: deciphering brain complexity in health and disease”, Nature Reviews Neurolog