How have new transcriptomic technologies changed our understanding of brain physiology in health and disease?New publication in Nature Reviews Neurology.

Dr. Monika Piwecka from the IBCH PAS in Poznań, together with scientists from the Max Delbrück Center for Molecular Medicine in Berlin, Dr. Agnieszka Rybak-Wolf and Prof. Nikolaus Rajewsky, has published a review article that summarizes several intensive years of work conducted with single-cell RNA sequencing and spatially-resolved transcriptomics in the context of brain biology. In the review including of more than 200 studies, the authors identified a few areas where these new transcriptomic technologies have had a particular impact, including: understanding of selective neuronal vulnerability, neuroimmune dysfunction and cell-type-specific treatment response. The authors also discuss the limitations and future directions of single-cell RNA sequencing and spatial transcriptomics in the context of neurological disorders. The online press release took place on May 17, 2023.

Piwecka M., Rajewsky N., Rybak-Wolf A. (2023) „Single-cell and spatial transcriptomics: deciphering brain complexity in health and disease”, Nature Reviews Neurolog

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