Department of Biomedical Proteomics

Dr. hab. Magdalena Łuczak, prof. IBCH PAS

Head of Department

magdalu@ibch.poznan.pl
Phone: 61 6653049, 61 8528503 ext. 1045

Researchers:

prof. dr hab. Maciej Figiel
profesor Instytutu

Research activity

Research area

proteomic analysis of the molecular basis of atherosclerosis in chronic kidney disease
analysis of the relationship between oxidative stress and chronic inflammation in chronic kidney disease and cardiovascular disease
identification of protein biomarkers of resistance to chemotherapy
analysis of the mechanism of cell resistance to proteasome inhibitors
wide spectrum of technical approaches: electrophoresis, immunoenzymatic methods, liquid and gas chromatography, mass spectrometry, microscopy, bioinformatic analysis of proteomics data.

Keywords

Proteomics,
proteins,
mass spectrometry,
chronic kidney disease,
cardiovascular disease,
multiple myeloma,
oxidative stress,
inflammation

Research Projects

Comprehensive phosphoproteomic analysis of NKT cells in the context of the role of phosphorylation mechanisms in progression of atherosclerosis in chronic kidney disease. NCN - OPUS22
Molecular mechanism of atherosclerosis progression in chronic kidney disease.
NSC – OPUS 10
Proteomic analysis of myeloma plasma cells to determine proteins and pathways involved in acquired resistance to proteasome inhibitors. NCN - OPUS13

Selected publications

J.Watral, D. Formanowicz, B. Perek, K. Kostka-Jeziorny, A. Podkowińska, A. Tykarski, M. Luczak. Comprehensive proteomics of monocytes indicates oxidative imbalance functionally related to inflammatory response in chronic kidney disease-related atherosclerosis. Frontiers in Molecular Biosciences, DOI: 10.3389/fmolb.2024.1229648. (2024)
A. Pacholak, J. Zur-Pinska, A. Pinski, QA. Nguyen, M. Ligaj, M. Luczak, LD. Nghiem, E. Kaczorek. Potential negative effect of long-term exposure to nitrofurans on bacteria isolated from wastewater. Sci. Total Environ. 872; 162199 (2023).
T. Kubicki, K. Bednarek, M. Kostrzewska-Poczekaj, M. Luczak, Z. Kanduła, K. Lewandowski, L. Gil, M. Jarmuż-Szymczak, D. Dytfeld. Bortezomib- and carfilzomib-resistant myeloma cells show increased activity of all three arms of the unfolded protein response. Am J Cancer Res 12(7); 3280-3293 (2022).
H. Ehrlich, M. Luczak, R. Ziganshin, I. Miksik, M. Wysokowski, P. Simon, I. Baranowska-Bosiacka, P. Kupnicka, A. Ereskovsky, R. Galli, S. Dyshlovoy, J. Fischer, K. Tabachnick, I. Petrenko, T. Jesionowski, A. Lubkowska, M. Figlerowicz, V. Ivanenko, A. Summers. Arrested in Glass: Actin within Sophisticated Architectures of Biosilica in Sponges. Advanced Science, e2105059 (2022).
J. Tracz, M. Luczak. Applying Proteomics and Integrative „Omics” Strategies to Decipher the Chronic Kidney Disease-Related Atherosclerosis. International Journal of Molecular Sciences, 22: 7492 (2021).
L. Marczak, J. Idkowiak, J. Tracz, M. Stobiecki, B. Perek, K. Kostka-Jeziorny, A. Tykarski, M. Wanic-Kossowska, M. Borowski, M. Osuch, D. Formanowicz, M. Luczak. Mass- Spectrometry-Based Lipidomics Reveals Differential Changes in the Accumulated Lipid Classes in Chronic Kidney Disease. Metabolites, 11, 275 (2021).
J. Tracz, L. Handschuh, M. Lalowski, Ł Marczak, K. Kostka-Jeziorny, B. Perek, M. Wanic-Kossowska, A. Podkowińska, A. Tykarski, D. Formanowicz, M. Luczak. Proteomic Profiling of Leukocytes Reveals Dysregulation of Adhesion and Integrin Proteins in Chronic Kidney Disease-Related Atherosclerosis. Journal of Proteome Research 20; 6, 3053-3067 (2021).
Y. Uchida, R. Goto, H. Takeuchi, M. Luczak, T. Usui, M. Tachikawa, T. Terasaki. Abundant expression of OCT2, MATE1, OAT1, OAT3, PEPT2, BCRP, MDR1 and xCT transporters in blood-arachnoid barrier of pig, and polarized localizations at CSF- and blood-facing plasma membranes. Drug Metabolism and Disposition, 48, 135-145 (2020).

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Department of Biomedical Proteomics

Researchers:

Technical Staff:

PhD students:

Affiliated professors:

Research activity

Research area

Keywords

Research Projects

Selected publications

Adres

Address

Department of Biomedical Proteomics

Researchers:

Technical Staff:

PhD students:

Affiliated professors:

Research activity

Research area

Keywords

rys. 1

Research Projects

Selected publications

Adres

Address