Laboratory of Medicinal Chemistry

Dr. Dorota Jakubczyk

Head of Laboratory

djakubczyk@ibch.poznan.pl
ext. 1165

Research Projects

Keywords:

Medicinal chemistry
“Hit to lead” – molecules optimisation
Chemical Synthesis
Biosynthesis, biocatalysis, semi-synthesis
Isolation and identification of products
Natural products
Chemoinformatics

Offer

Chemical synthesis of bioactive molecules
“Hit to lead” – molecules optimisation – chemoinformatic design and the synthesis
Biosynthesis, biocatalysis, semi-synthesis for compounds difficult to synthesise using classical synthetic chemistry
Selection of already existing libraries for bioactivity tests
Automated isolation and purification of chemical compounds - from biological material or enzymatic reactions

Equipment

Chromatograph Flash Biotage® Selekt
LCMS-8040 Shimadzu

Projekty badawcze

POL-OPENSCREEN 2.0 - Maintenance, Development and Sharing of the Polish Screening Infrastructure Platform for Biological Chemistry, in view of the Participation in the EU-OPENSCREEN ERIC Research Infrastructure Consortium)

FENG.02.04-IP.04-0010/24-00
POL-OPENSCREEN – Polska Platforma Infrastruktury Skriningowej dla Chemii Biologicznej
Projekt finansowany przez Ministerstwo Nauki i Szkolnictwa Wyższego w ramach Programu Fundusze Europejskie dla Nowoczesnej Gospodarki 2021- 2027 działanie 2.4.

OPUS 2024/53/B/NZ5/01942
Comprehensive structural and functional analysis of p53 mRNA to identify secondary and tertiary RNA structures important in physiology, carcinogenesis, and development of therapies against human diseases.

Selected publications

Gawel M., Malecki P.H., Sliwiak J., Stepniewska M., Imiolczyk B., Czyrko-Horczak J., Jakubczyk D., Marczak Ł., Plonska-Brzezinska M. E., Brzezinski K., A closer look at molecular mechanisms underlying inhibition of S-adenosyl-L-homocysteine hydrolase by transition metal cations. ChemComm (2024), 60, 11504 - 11507
Totoń E.*, Lisiak N., Romaniuk-Drapała A., Framski G., Wyszko E., Ostrowski T.*, Cytotoxic effects of kinetin riboside and its selected analogues on cancer cell lines. Bioorg. Med. Chem. Lett. (2024) 100:129628
Błaszczyk L., Ryczek M., Das B., Mateja-Pluta M., Bejger M., Śliwiak J., Nakatani K., Kiliszek A., Antisense RNA C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms a triplex-like structure and binds small synthetic ligand. Nucleic Acids Res. (2024) 52, 11
Ostrowski T.*, Bioactive furanyl- or thienyl-substituted nucleobases, nucleosides and their analogues. Mini-Rev. Med. Chem. (2023) 23:633-650
Kiliszek A., Rypniewski W., Błaszczyk L.*, Exploring structural determinants and the role of nucleolin in formation of the long-range interactions between untranslated regions of p53 mRNA. RNA (2023), 29, 5
Dussart F., Jakubczyk D.*, Biosynthesis of Rubellins in Ramularia collo-cygni — Genetic Basis and Pathway Proposition. Int. J. Mol. Sci. (2022), 23, 3475
Baranowski D., Boryski J., Ostrowski T.*, 7-(β-D-Ribofuranosyl)-3-methylguanine: synthesis from guanine and comparative multinuclear NMR studies. J. Mol. Struct. (2022) 1250:131911
Orlicka-Płocka M., Fedoruk-Wyszomirska A., Gurda-Woźna D., Pawelczak P., Krawczyk P., Giel-Pietraszuk M., Framski G., Ostrowski T., Wyszko E.*, Implications of oxidative stress in glioblastoma multiforme following treatment with purine derivatives. Antioxidants (2021) 10:950
Jakubczyk D.*, Francois D. Selected Fungal Natural Products with Antimicrobial Properties. Molecules (2020), 25, 911: 1-18
Wawrzyniak D., Framski G., Januszczyk P., Ostrowski T., Baraniak D., Jahnz-Wechmann Z., Fogt J., Manikowski A., Baranowski D., Rolle K., Boryski J.*, 7-(β-D-Ribofuranosyl)guanine and its analogues modified in the sugar portion: synthesis and antiglioma properties. ChemistrySelect (2020) 5:13370-13375
Baranowski D., Framski G., Wyszko E.*, Ostrowski T.*, Studies on structure of kinetin riboside and its analogues by variable-temperature NMR. J. Mol. Struct. (2019) 1195:110-118
Troszok A., Kolek L., Szczygieł J., Ostrowski T., Adamek M., Irnazarow I.*, Anti-CyHV-3 effect of fluorescent, tricyclic derivative of acyclovir 6-(4-MeOPh)-TACV in vitro. J. Vet. Res. (2019) 63:513-518
Mukherjee S., Błaszczyk L., Rypniewski W., Falschlunger C., Micura R., Murata A., Dohno C., Nakatani K., Kiliszek A., Structural insights into synthetic ligands targeting A-A pairs in disease-related CAG RNA repeats. Nucleic Acids Res. (2019), 47, 20
Jakubczyk D., Caputi L., Stevenson C. E. M., Lawson D. M., O’Connor S. E. Structural characterization of EasH (Aspergillus japonicus) – an oxidase involved in cycloclavine biosynthesis. Chem. Comm. (2016) 52: 14306-14309
Jakubczyk D., Caputi L., Hatsch A., Nielsen C. A. F., Diefenbacher M., Klein J., Molt A., Schroeder H., Cheng J. Z., Naesby M., O’Connor S. E. Discovery and reconstitution of the cycloclavine biosynthetic pathway — enzymatic formation of a cyclopropyl group. Angew. Chem. Int. Ed. (2015) 54: 5117 –5121
Jakubczyk D., Cheng J. Z., O'Connor S. E. Biosynthesis of the ergot alkaloids. Nat. Prod. Rep. (2014) 31: 1328-1338

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