Department of Medical Biology

prof. dr hab. Mirosława Z. Naskręt-Barciszewska

Prof. Mirosława Z. Naskręt-Barciszewska, associate professor

Head of Department

miroslawa.barciszewska@ibch.poznan.pl
ext. 1132

Research activity

Research area

The research activity of the Department focuses on studies of new molecular markers of neoplastic and metabolic diseases as well as developing new therapeutic approaches with nucleic acids and their derivatives.
We are working on:

Construction of new ribozymes and DNAzymes for the inhibition of miRNA (A),
Analysis of the secondary structure of miRNAs specific for brain tumors using catalytic RNAs (B),
Analysis of the content of 5-methylcytosine in DNA from brain tumors and other human pathologies (C),
Assessment of 5-methylcytosine content in DNA from deciduous seeds,
Analysis of non-coding RNAs in humans and in plants,
Determination of the content of 8-oxoguanosine and m5C in DNA from brain tumors (D),
Application of low molecular weight compounds in the therapy of brain tumors.

Keywords

DNA methylation,
human brain tumors ,
cancers,
modified nucleosides,
miRNA,
ribozymes,
8-oxoguanosine.

Research Projects

Pioniering structural and funcional studies of miRNA G-quadruplexes.

Selected publications

M. Michalak, M.Z. Barciszewska, J. Barciszewski, B.P. Plitta, P. Chmielarz (2013) Global Changes in DNA Methylation in Seeds and Seedlings of Pyrus communis after Seed Desiccation and Storage. PLoS One 8(8), e70693.
A-M. Barciszewska, S. Nowak, M.Z. Naskręt-Barciszewska. (2014)The Degree of Global DNA Hypomethylation in Peripheral Blood Correlates with that in Matched Tumor Tissues in Several neoplasia. PLoS One 9(3), e92599.
Belter, D. Gudanis, K. Rolle, M. Piwecka, Z. Gdaniec, MZ. Naskręt-Barciszewska, J. Barciszewski. (2014) Mature miRNAs form secondary structure, which suggests their function beyond RISC. PLoS One 9(11): e113848.
M. Doniak , MZ. Barciszewska, J. Kaźmierczak, A. Kaźmierczak. (2015) The crucial elements of the 'last step' of programmed cell death induced by kinetin in root cortex of V. faba ssp. minor seedlings. Plant Cell Rep DOI 10.1007/s00299-014-1681-9.
A-M. Barciszewska,D. Gurda, P. Głodowicz, S. Nowak, MZ. Naskręt-Barciszewska (2015) A new epigenetic mechanism of temozolomide action in glioma cells. PloS ONE 10(8):e136669.
MZ. Barciszewska, PP Perrigue, J Barciszewski. (2016) tRNA – the golden standard in molecular biology. Molecular BioSystems. 12, 12-17.
Belter, K. Rolle, M. Piwecka, M. A. Fedoruk-Wyszomirska, MZ Naskręt-Barciszewska, J.Barciszewski. (2016) Inhibition of miR-21 in glioma cells using catalytic nucleic acids" Scientific Reports. 6:24516.
M. Olszewska, MZ. Barciszewska, M. Fraczek, N. Huleyuk, V B. Chernykh, D. Zastavna, J. Barciszewski, M. Kurpisz. (2017) Global methylation status of sperm DNA in carriers of chromosome structural aberrations Asian Journal of Andrology 18, 1-8.
K. Rolle, M. Piwecka, A. Belter, D. Wawrzyniak, J. Jeleniewicz, MZ. Barciszewska, J. Barciszewski. (2016) The sequence and structure determine the function of mature human miRNAs. PLoS ONE 11(3): e0151246
BP. Plitta-Michalak, M.Z. Naskręt-Barciszewska, S. Kotlarski, D. Tomaszewski, T. Tylkowski, J. Barciszewski, P. Chmielarz, M. Michalak. (2018) Changes in genomic 5-methylcytosine level mirror the response of orthodox (Acer platanoides L.) and recalcitrant (Acer pseudoplatanus L.) seeds to severe desiccation. Tree Physiol 38(4) 617-629. doi: 10.1093/treephys/tpx134
AM. Barciszewska, M. Giel-Pietraszuk, PM. Perrigue, M. Naskręt-Barciszewska. (2019) Total DNA methylation changes reflect random oxidative DNA damage in gliomas. Cells 8 1065;doi 10.3390/cells8091065
Patrick M. Perrigue *, Magdalena Rakoczy, Kamila Pawlicka, Agnieszka Belter, Małgorzata Giel-Pietraszuk, Mirosława Naskręt-Barciszewska, Jan Barciszewski, Marek Figlerowicz. (2020) Cancer stem cell-inducing media activates senescence reprogramming in fibroblasts. Cancers (Basel). 12(7):E1745. doi: 10.3390/cancers12071745.
Belter A, Barciszewski J, Barciszewska AM (2020) Revealing the epigenetic effect of temozolomide on glioblastoma cell lines in therapeutic conditions. PLoS ONE 15(2): e0229534. https://doi.org/10.1371/journal.pone.0229534

IBCH logo

Department of Medical Biology

Technical Staff:

Research activity

Research area

Keywords

Research Projects

Selected publications

Adres

Address

Department of Medical Biology

Technical Staff:

Research activity

Research area

Keywords

rys2 zbm

rys2-zbm

rys3-zbm

D

Research Projects

Selected publications

Adres

Address