The project titled "Improving User Experience, Long-term Sustainability and Services of EU-OPENSCREEN (IMPULSE)" is co-financed by the Polish state budget in the years 2025–2027. 
The funding was obtained under the "International Co-financed Projects" programme. The amount of funding is PLN 88,466, while the total project value is PLN 99,126. The Principal Investigator of the international IMPULSE project is Jacek Kolanowski, PhD, DSc, while the Principal Investigator of the project funded by the Ministry is Dorota Kwiatek-Rożek, PhD. 
IMPULSE (IMProving User experience, Long-term Sustainability and Services of EU-OPENSCREEN) is an international research project implemented under the Horizon Europe programme. Its objective is to develop, integrate, and validate new research methods and technologies in the fields of chemical biology and early drug discovery. The project focuses on the development of new scientific services and analytical tools that will enable more efficient research on bioactive compounds, their mechanisms of action, and their therapeutic potential. 
The project directly contributes to the development of the European Research Area (ERA), strengthens international collaboration, and enhances the capacity of Polish research institutions in the field of advanced biomedical research.

In the years 2023-2025, at the Institute of Biochemistry of the Polish Academy of Sciences in the Department of Genetic Engineering a project titled: “The influence of CAG tract length polymorphism on the pathogenesis of neoplastic diseases" under the Perły Nauki program. The principal investigator is Marianna Karwacka, MSc. Neurodegenerative diseases and cancer are one of the leading diseases of the elderly age. The cause of neurodegenerative polyglutamine (polyQ) diseases, including spinal and bulbar muscular atrophy (SBMA), is the expansion of CAG trinucleotide repeats in the AR gene. At the same time, the androgen receptor, encoded by the AR gene, is a protein of great importance for the development and progression of cancer. A surprising and unexplained phenomenon is the lower incidence of cancer in patients with polyQ diseases. The aim of the project is to examine how CAG repeats of different lengths affect phenotypic features typical of cancer cells and tumor progression. The project involves the generation of cellular models of prostate and ovarian cancer containing long CAG repeats and a SBMA cellular model with short CAG repeats in the AR gene using the CRISPR-Cas9 system. Next, the cancer features of the created cell models, such as the ability to proliferate, migrate and response to cellular stress, will be examined, and their gene expression profiles will be analyzed. The obtained results will allow us to understand what mechanisms may be responsible for the protective effect of long CAG sequences in cancer diseases, which may be used in the future to develop new therapeutic approaches.