Research area

• development of novel molecular tools and devices based on nucleic acids and their analogues,
• chemical synthesis of modified nucleosides and oligonucleotides,
• thermodynamic and structural (CD, TDS) analysis of various nucleic acids motifs
• (e.g. G-quadruplexes, triplexes, i-motif),
• thermodynamics of siRNAs,
• regulation of siRNA strand selection by RISC complex using modified nucleotides,
• allele-selective degradation of mRNA via chemically modified siRNAs,
• alternative splicing regulation in cancer cell lines,
• development of potent anticoagulants based on modified oligonucleotides,
• in vitro studies of chemically modified G-quadruplexes and their antiproliferative properties,
• chemical synthesis of novel dyes with potential photodynamic activity.

As co-investigators:

• in vitro studies of dye-oligonucleotide conjugates as useful tools for photodynamic therapy (Principal investigator: Michał Kotkowiak, PhD, Faculty of Technical Physics, Institute of Physics, Poznan University of Technology, Poznań, Poland),
• studies on therapeutic potential of antisense oligonucleotides in gene silencing process (Prof. Jesper Wengel, University of Southern Denmark, Odense)