Department of Structural Biology of Prokaryotic Organisms

kbrzezinski@ibch.poznan.pl

Dr. hab. Krzysztof Brzeziński​, prof. IBCH PAS

Head of Department

kbrzezinski@ibch.poznan.pl
ext. 1125

Researchers:

Dr. Piotr H. Małecki 
adiunkt

Dr. ​Magdalena Bejger
adiunkt

Technical Staff:

Dr. Marta Wojnicka
specialist biologist

Marlena ​Stępniewska MSc
specialist biologist

Research activity

Research area

To develop novel inhibition strategies against enzymes of pathogenic origin, a broad range of methods from the intersection of microbiology, biochemistry, biophysics including macromolecular crystallography  and NMR spectroscopy, must be applied. Our studies concern:

  • Structural enzymology of S-adenosyl-L-homocysteine hydrolases of various origin.
  • Development of species-specific inhibitors targeting the enzyme dynamics.
  • High-throughput macromolecular crystallography.
  • Crystallographic studies of biologically active small molecules.
  • X-ray diffraction studies of non-crystalline (bio)materials.
Keywords
  • Macromolecular crystallography
  • Small molecule crystallography
  • Structural enzymology
  • Protein-ligand interactions
  • Antibiotic resistance
  • Cellular methylation
  • S-adenosyl-L-homocysteine hydrolase

Research Projects

Rational, structure-guided design of histone demethylase inhibitors for cancer therapy 
NCN SONATA 17

Inhibition of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa by targeting the enzyme dynamics
NCN SONATA BIS 8

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