CMC, a list of cancer-related miRNA genes published in Nucleic Acids Research by researchers from IBCH PAS

The researchers from Piotr Kozłowski’s team, in collaboration with the Laboratory of Bioinformatics, including Malwina Suszyńska, Magda Machowska, Eliza Fraszczyk, Maciej Michalczyk, Anna Philips, and Paulina Gałka-Marciniak, developed the Cancer miRNA Census (CMC), the first comprehensive list and score of cancer-related miRNA genes. The list was constructed based on several independent criteria and validated by comparisons with numerous cancer data sets. The CMC may be used as a reference for the validation of results of miRNA analyses in cancer, the prioritization of miRNAs in different cancer analyses, and the optimization of methods for identifying further cancer-related miRNAs or cancer-driver miRNA genes. A CMC search is possible via the CMC Cancer Genome Census portal, https://cmc.ibch.poznan.pl/.

Link to the article:

https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae017/7585677

The chart illustrates the classification of miRNA genes based on criteria such as miRCancer, dbDEMC, oncomiRDB, consistency, hallmarks, KEGG, and mutations, separating them by a cutoff line into non-CMC ($n=469$) and CMC (Cancer miRNA Census, $n=165$) groups. On the right side, above the cutoff line, selected genes are labeled, including MIR21, MIR155, MIR16-1, MIR15A, MIR17, and MIRLET7B.
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